Biodegradable hydrogel with nanogel cross-linked structure as artificial extracellular matrix

Urara Hasegawa, Nobuyuki Morimoto, Kazunari Akiyoshi

Research output: Contribution to conferencePaperpeer-review


We previously reported that the nanogel of cholesterol-bearing pullulan (CHP) served as a promising carrier for proteins and hydrophobic drugs. In this study, we developed biodegradable hydrrogel with nanogel cross-linked structure (CHPA-PEOSH gel) for tissue engineering. CHPA-PEOSH gel was prepared by Micheal addition of acryloyl group-modified CHP (CHPA) and mercapto group-modified polyethylene oxide (PEOSH). This hydrogel degraded more rapidly in 10% serum-containing medium than in phosphate buffered saline. CHPA-PEOSH gel is a promising candidate as an artificial extracellular matrix for long-term drug release.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Oct 19
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26


Other55th SPSJ Annual Meeting


  • Artificial extracellular matrix
  • Biodegradable
  • Drug delivery system
  • Hydrogel
  • Nanogel

ASJC Scopus subject areas

  • Engineering(all)


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