Bioconjugated Hydrogels for Tissue Engineering and Regenerative Medicine

Samad Ahadian, Ramin Banan Sadeghian, Sahar Salehi, Serge Ostrovidov, Hojae Bae, Murugan Ramalingam, Ali Khademhosseini

    Research output: Contribution to journalReview articlepeer-review

    89 Citations (Scopus)


    Hydrogels are hydrophilic polymer networks with high water content, which have played an important role as scaffolds for cells, as carriers for various biomolecules (e.g., drugs, genes, and soluble factors), and as injectable biomaterials in tissue engineering (TE) and regenerative medicine. Bioconjugation is an approach for improving the performance of hydrogels using cell-responsive components, such as proteins and peptides, which have high affinity to regulate cellular behaviors and tissue morphogenesis. However, the current knowledge on the role of those bioconjugated moieties in controlling cellular functions and tissue morphogenesis and bioconjugation methods are limited in the context of TE and organogenesis. Moreover, micro- and nanofabrication techniques have been used to manipulate bioconjugated hydrogels for regulating cell behaviors and function. This Review therefore describes synthesis, characteristics, and manipulation of various bioconjugated hydrogels and their potential in TE applications with special emphasis on preclinical/clinical translation.

    Original languageEnglish
    Pages (from-to)1984-2001
    Number of pages18
    JournalBioconjugate chemistry
    Issue number10
    Publication statusPublished - 2015 Oct 21

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Biomedical Engineering
    • Pharmacology
    • Pharmaceutical Science
    • Organic Chemistry


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