Biochemical markers of bone turnover. New aspect. Nitric oxide synthase and bone metabolism

Ken Sabanai; Masato Tsutsui; Akinori Sakai; Toshitaka Nakamura; Hiroaki Shimokawa; Nobuyuki Yanagihara

Biochemical markers of bone turnover. New aspect. Nitric oxide synthase and bone metabolism

Ken Sabanai, Masato Tsutsui, Akinori Sakai, Toshitaka Nakamura, Hiroaki Shimokawa, Nobuyuki Yanagihara

MED - Medical Sciences

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

It remains to be determined the role of the nitric oxide synthase (NOS) system in bone metabolism. We addressed this point in mice with complete disruption of the NOS system (triply n/i/eNOS(-/-) mice) that we have recently developed, and clarified that the triply NOS( - / - ) mice manifested increased bone mineral density and accelerated bone turnover in vivo. These results provide the first direct evidence that the entire NOS system plays an important role in the regulation of bone metabolism.

Original language	English
Pages (from-to)	1133-1141
Number of pages	9
Journal	Clinical calcium
Volume	19
Issue number	8
Publication status	Published - 2009 Aug

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Biochemical markers of bone turnover. New aspect. Nitric oxide synthase and bone metabolism",

abstract = "It remains to be determined the role of the nitric oxide synthase (NOS) system in bone metabolism. We addressed this point in mice with complete disruption of the NOS system (triply n/i/eNOS(-/-) mice) that we have recently developed, and clarified that the triply NOS( - / - ) mice manifested increased bone mineral density and accelerated bone turnover in vivo. These results provide the first direct evidence that the entire NOS system plays an important role in the regulation of bone metabolism.",

author = "Ken Sabanai and Masato Tsutsui and Akinori Sakai and Toshitaka Nakamura and Hiroaki Shimokawa and Nobuyuki Yanagihara",

year = "2009",

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journal = "Clinical calcium",

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T1 - Biochemical markers of bone turnover. New aspect. Nitric oxide synthase and bone metabolism

AU - Sabanai, Ken

AU - Tsutsui, Masato

AU - Sakai, Akinori

AU - Nakamura, Toshitaka

AU - Shimokawa, Hiroaki

AU - Yanagihara, Nobuyuki

PY - 2009/8

Y1 - 2009/8

N2 - It remains to be determined the role of the nitric oxide synthase (NOS) system in bone metabolism. We addressed this point in mice with complete disruption of the NOS system (triply n/i/eNOS(-/-) mice) that we have recently developed, and clarified that the triply NOS( - / - ) mice manifested increased bone mineral density and accelerated bone turnover in vivo. These results provide the first direct evidence that the entire NOS system plays an important role in the regulation of bone metabolism.

AB - It remains to be determined the role of the nitric oxide synthase (NOS) system in bone metabolism. We addressed this point in mice with complete disruption of the NOS system (triply n/i/eNOS(-/-) mice) that we have recently developed, and clarified that the triply NOS( - / - ) mice manifested increased bone mineral density and accelerated bone turnover in vivo. These results provide the first direct evidence that the entire NOS system plays an important role in the regulation of bone metabolism.

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M3 - Review article

C2 - 19638697

AN - SCOPUS:70350706637

SN - 0917-5857

VL - 19

SP - 1133

EP - 1141

JO - Clinical calcium

JF - Clinical calcium

IS - 8

ER -

Biochemical markers of bone turnover. New aspect. Nitric oxide synthase and bone metabolism

Abstract

ASJC Scopus subject areas

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