Biochemical evaluation of an artificial anal sphincter made from shape memory alloys

Hongjian Liu, Yun Luo, Masaru Higa, Xiumin Zhang, Yoshifumi Saijo, Yasuyuki Shiraishi, Kazumitsu Sekine, Tomoyuki Yambe

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Severe anal incontinence is a socially incapacitating disorder and a major unresolved clinical problem that has a considerable negative impact on quality of life. In this study, we developed a new artificial anal sphincter using shape memory alloys (SMAs) in order to improve the quality of life of such patients and evaluated the influence of this sphincter on blood serum chemistry in animal experiments. The artificial anal sphincter was driven by two Ti-Ni SMA actuators sandwiching the intestine and was implanted in three female goats. Blood was collected from the jugular vein on days 1 and 4; at weeks 1 and 2; and at months 1, 2, and 3, postoperatively. Biochemical parameters including total protein, albumin, total bilirubin, aspartate amino-transferase, blood urea nitrogen, creatinine, and C-reactive protein were examined. The time courses of total bilirubin and aspartate amino transferase of the three goats were within the baseline levels after 1 week of implantation and remained normal, demonstrating no liver function complications. The blood urea nitrogen and creatinine levels remained within the normal range, indicating no renal function complications. The total protein and albumin fluctuated within the normal range throughout the duration of this study. In these goats, it was also found that the level of C-reactive protein did not increase and that there was no stricture of the intestine where the artificial sphincter was attached. Our findings indicate that the artificial sphincter SMA demonstrated no adverse influence on blood serum chemistry and exhibited an effective system performance.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalJournal of Artificial Organs
Volume10
Issue number4
DOIs
Publication statusPublished - 2007 Dec

Keywords

  • Artificial anal sphincter
  • Biochemical evaluations
  • Goat
  • Implantation
  • Shape memory alloys

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine

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