Bioactivity and mechanical properties of polydimethylsiloxane (PDMS)-CaO-SiO2 hybrids with different calcium contents

M. Kamitakahara, M. Kawashita, N. Miyata, T. Kokubo, T. Nakamura

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Polydimethylsiloxane (PDMS)-CaO-SiO2 hybrids with starting compositions containing PDMS/(Si(OC2H5)4 + PDMS) weight ratio = 0.30, H2O/Si(OC2H5)4 molar ratio = 2, and Ca(NO3)2/Si(OC2H5)4 molar ratios = 0-0.2, were prepared by the sol-gel method. The apatite-forming ability of the hybrids increased with increasing calcium content in the Ca(NO3)2/Si(OC2H5)4 molar ratio range 0-0.1. The hybrids with a Ca(NO3)2/Si(OC2H5)4 molar ratio range 0.1-0.2 formed apatite on their surfaces in a simulated body fluid (SBF) within 12 h. The hybrid with a Ca(NO3)2/Si(OC2H5)4 molar ratio of 0.10 showed an excellent apatite-forming ability in SBF with a low release of silicon into SBF. It also showed mechanical properties analogous to those of human cancellous bones. This hybrid is expected to be useful as a new type of bioactive material.

Original languageEnglish
Pages (from-to)1015-1020
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Volume13
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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