Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

Yuanqiang Guo, Yushan Li, Jing Xu, Ryuichi Watanabe, Yasukatsu Oshima, Tohru Yamakuni, Yasushi Ohizumi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Original languageEnglish
Pages (from-to)274-276
Number of pages3
JournalJournal of Natural Products
Volume69
Issue number2
DOIs
Publication statusPublished - 2006 Feb 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Guo, Y., Li, Y., Xu, J., Watanabe, R., Oshima, Y., Yamakuni, T., & Ohizumi, Y. (2006). Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana. Journal of Natural Products, 69(2), 274-276. https://doi.org/10.1021/np050276q