Abstract
Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.
| Original language | English |
|---|---|
| Pages (from-to) | 274-276 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 69 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2006 Feb 1 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Cite this
Guo, Y., Li, Y., Xu, J., Watanabe, R., Oshima, Y., Yamakuni, T., & Ohizumi, Y. (2006). Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana. Journal of Natural Products, 69(2), 274-276. https://doi.org/10.1021/np050276q