Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

Yuanqiang Guo; Yushan Li; Jing Xu; Ryuichi Watanabe; Yasukatsu Oshima; Tohru Yamakuni; Yasushi Ohizumi

doi:10.1021/np050276q

Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

Yuanqiang Guo, Yushan Li, Jing Xu, Ryuichi Watanabe, Yasukatsu Oshima, Tohru Yamakuni, Yasushi Ohizumi

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Original language	English
Pages (from-to)	274-276
Number of pages	3
Journal	Journal of Natural Products
Volume	69
Issue number	2
DOIs	https://doi.org/10.1021/np050276q
Publication status	Published - 2006 Feb
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np050276q

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title = "Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana",

abstract = "Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.",

author = "Yuanqiang Guo and Yushan Li and Jing Xu and Ryuichi Watanabe and Yasukatsu Oshima and Tohru Yamakuni and Yasushi Ohizumi",

year = "2006",

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doi = "10.1021/np050276q",

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volume = "69",

pages = "274--276",

journal = "Journal of Natural Products",

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T1 - Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

AU - Guo, Yuanqiang

AU - Li, Yushan

AU - Xu, Jing

AU - Watanabe, Ryuichi

AU - Oshima, Yasukatsu

AU - Yamakuni, Tohru

AU - Ohizumi, Yasushi

PY - 2006/2

Y1 - 2006/2

N2 - Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

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Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

Abstract

ASJC Scopus subject areas

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