Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

Yuanqiang Guo; Yushan Li; Jing Xu; Ryuichi Watanabe; Yasukatsu Oshima; Tohru Yamakuni; Yasushi Ohizumi

doi:10.1021/np050276q

Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

Yuanqiang Guo, Yushan Li, Jing Xu, Ryuichi Watanabe, Yasukatsu Oshima, Tohru Yamakuni, Yasushi Ohizumi

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

Original language	English
Pages (from-to)	274-276
Number of pages	3
Journal	Journal of Natural Products
Volume	69
Issue number	2
DOIs	https://doi.org/10.1021/np050276q
Publication status	Published - 2006 Feb

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np050276q

Fingerprint Dive into the research topics of 'Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana'. Together they form a unique fingerprint.

Cite this

@article{8977543d990641a9b63c684af5c06aa0,

title = "Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana",

abstract = "Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.",

author = "Yuanqiang Guo and Yushan Li and Jing Xu and Ryuichi Watanabe and Yasukatsu Oshima and Tohru Yamakuni and Yasushi Ohizumi",

year = "2006",

month = feb,

doi = "10.1021/np050276q",

language = "English",

volume = "69",

pages = "274--276",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

AU - Guo, Yuanqiang

AU - Li, Yushan

AU - Xu, Jing

AU - Watanabe, Ryuichi

AU - Oshima, Yasukatsu

AU - Yamakuni, Tohru

AU - Ohizumi, Yasushi

PY - 2006/2

Y1 - 2006/2

N2 - Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

AB - Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid methyl ester-18,19-olide (3), on the basis of spectroscopic data analysis. A known compound, 7-oxo-ent-clerod-3- en-15,16:18,19-diolide, was also identified. Compounds 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

UR - http://www.scopus.com/inward/record.url?scp=33644890455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644890455&partnerID=8YFLogxK

U2 - 10.1021/np050276q

DO - 10.1021/np050276q

M3 - Article

C2 - 16499330

AN - SCOPUS:33644890455

VL - 69

SP - 274

EP - 276

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 2

ER -