Bio-imaging by functional nano-particles of nano to macro scale

M. Takeda, H. Tada, M. Kawai, Y. Sakurai, H. Higuchi, K. Gonda, T. Ishida, Noriaki Ohuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Nano-materials are expected to be used for medical applications such as research on pharmacokinetics and novel therapeutic agents. Their acute toxicity should be examined and systemic distribution of the nano-materials should also be estimated. We established a high resolution in vivo 3D microscopic system for a novel fluorescence imaging method at single molecular level. We measured in vivo movement of CdSe nano-particles (quantum dots (QDs)) conjugated with monoclonal anti-HER2 antibody (Trastuzumab) in tumor vessel to breast cancer cells. The HER2 protein expressed in cancer cells and its in vivo dynamics were visualized by QDs at nano-scale. It suggests future utilization of the system to improve drug delivery system to target the primary and metastatic tumors for made to order treatment. We also describe a novel contrast medium for X-ray and its distribution in organs. Nano-sized silica coated silver iodide beads exhibited contrast enhancementin the tumor for over one hour. Sentinel node navigation is one of the important clinical applications for fluorescence nano-particles and silver iodide beads. Our experimental data of those nano-particles in experimental model have shown the potential of fluorescence and X-ray measurement to be alternatives to existing tracers. Future innovation in cancer imaging by nano-technology and novel measurement technology will provide great improvement, not only in clinical field of prevention, diagnosis and treatment of human disease, but also in basic medical science.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages2272-2274
Number of pages3
DOIs
Publication statusPublished - 2009
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
Country/TerritorySingapore
Period08/12/308/12/6

Keywords

  • HER2
  • Single molecular imaging
  • nano-technology
  • quantum dots
  • silica coated silver iodide beads

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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