Bile acid and colorectal cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Colorectal cancer is one of the most common causes of cancer death worldwide. The mechanism of colorectal carcinogenesis is still unknown, so that the prevention of colorectal cancer is strongly desired. The bile acids, cholesterol derivatives, were thought to be implicated in the pathogenesis of many diseases. In particular, secondary bile acids are thought to be associated with the colorectal carcinogenesis regarding the colorectal mucosal proliferation, apoptosis, and oxidative DNA damage. On the other hand, certain bile acids, ursodeoxycholate, might protect against colorectal carcinogenesis. This review will examine the opposing effects on colorectal tumor promotion and tumor inhibition.

Original languageEnglish
Title of host publicationBile Acids in Gastroenterology
Subtitle of host publicationBasic and Clinical
PublisherSpringer Japan
Pages185-192
Number of pages8
ISBN (Electronic)9784431560623
ISBN (Print)9784431560609
DOIs
Publication statusPublished - 2017 Apr 3
Externally publishedYes

Keywords

  • Bile acid
  • Chemoprevention
  • Colorectal cancer
  • UDCA

ASJC Scopus subject areas

  • Medicine(all)

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