Abstract
A 55-year-old non-smoking woman was admitted to our hospital for re-evaluation of unimproved peripheral ground-glass opacities despite prednisolone and cyclosporine treatment. She was diagnosed with autoimmune pulmonary alveolar proteinosis (PAP) based on transbronchial lung biopsy and granulocyte/macrophage colony-stimulating factor (GM-CSF) antibody testing. GM-CSF inhalation therapy markedly improved the opacities. Bilateral, centrally located lung opacities are typical in PAP, however 10 PAP cases with peripheral infiltration were reported in Japan recently, of which GM-CSF antibody was positive in six. To avoid inappropriate immunosuppressant treatment, PAP should be considered in the differential diagnosis of such peripheral opacities. GM-CSF antibody might be useful for diagnosis.
Original language | English |
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Pages (from-to) | 1737-1742 |
Number of pages | 6 |
Journal | Internal Medicine |
Volume | 51 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |
Keywords
- GM-CSF antibody
- GM-CSF inhalation
- Pulmonary alveolar proteinosis
- Steroid therapy
- Subpleural infiltration
ASJC Scopus subject areas
- Internal Medicine