Bilateral aldosterone-producing adenomas in two patients diagnosed by immunohistochemical analysis of steroidogenic enzymes

Noriko Watanabe, Klazuo Tsunoda, Hironobu Sasano, Ken Omata, Yutaka Imai, Sadayoshi Ito, Keishi Abe

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Bilateral adrenal aldosterone-producing adenomas (APA) are rare. It is important to distinguish bilateral APA from idiopathic hyperaldosteronism (IHA), which is due to bilateral hyperplasia of the adrenal cortex. We present two patients with bilateral APA in whom the diagnosis was made histochemically by analyzing steroidogenic enzymes. They showed hypokalemia, high plasma aldosterone concentration (PAC) and suppressed plasma renin activity (PRA). Bilateral adrenal tumors were represented by computed tomography, and surgical resection was performed. In both cases, cytochrome P-450 and other enzymes that were involved in aldosterone synthesis were found mainly in tumor, but little in the zona glomerulosa of the adjacent adrenals, which showed paradoxical hyperplasia. Such cases are difficult to distinguish from IHA. The two disorders were differentiated by immunohistochemical analysis of steroidogenic enzymes.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalTohoku Journal of Experimental Medicine
Volume179
Issue number2
DOIs
Publication statusPublished - 1996 Jun

Keywords

  • adrenal gland
  • bilateral aldosterone producing adenomas
  • enzymatic analysis
  • idiopathic hyperaldosteronism
  • immunohistochemistry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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