Bezafibrate reduces blood glucose in type 2 diabetes mellitus

Susumu Ogawa, Kazuhisa Takeuchi, Kazuhiko Sugimura, Motoshi Fukuda, Ribun Lee, Sadayoshi Ito, Tokutaro Sato

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

The clinical efficacy of bezafibrate was examined with special reference to glucose metabolism in patients with type 2 diabetes mellitus (DM2). In protocol 1,342 patients with DM2 and hyperlipidemias were randomly divided into 2 groups, 16-week bezafibrate treatment (n = 174) and no bezafibrate treatment (n = 168). In protocol 2, 20 DM2 patients were randomly divided into 2 groups, 8-week bezafibrate treatment (n = 10) and no bezafibrate treatment (n = 10), and a meal tolerance test (MTT) was performed. In protocol 1, bezafibrate treatment significantly reduced the fasting levels of triglyceride (TG) by 50% ± 1.6%, total cholesterol (TC) by 12% ± 1.1%, plasma glucose (PG) from 151.3 ± 3.5 to 128.6 ± 3.4 mg/dL, and hemoglobin A(1c) (HbA(1c)) from 7.2% ± 0.1% to 6.9% ± 0.1%, and significantly increased high-density lipoprotein cholesterol (HDL-C) by 20% ± 0.8%. In protocol 2, fasting TG, PG, and insulin levels were significantly reduced by bezafibrate treatment. Moreover, in the MTT, postprandial increments of TG were significantly blunted after bezafibrate treatment, whereas postprandial PG and insulin levels were not significantly changed. Leptin levels were significantly decreased, while tumor necrosis factor alpha (TNF-α) levels were not changed. In conclusion, both hyperglycemia and hyperlipidemia can be improved by bezafibrate treatment in DM2. (C) 2000 by W.B. Saunders Company.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalMetabolism: Clinical and Experimental
Volume49
Issue number3
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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