beta-Lactamase activity in sputum and indirect pathogenicity.

A. Watanabe, K. Oizumi, M. Motomiya

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    Abstract

    beta-Lactamase activity of sputum of 39 patients with respiratory infections and that of bacterial isolates from their sputum were determined by nitrocefin method. Forty-six microbial strains (16 different species) were recovered from 39 sputum samples. The beta-lactamase activity was negative only in nine of the 46 strains. beta-lactamase-positive strains were recovered from 35 of 39 sputum samples. Of these 35 sputum samples, the beta-lactamase activity was positive in 23 and negative in 12. beta-lactamase-negative strains were recovered from 4 of 39 sputum samples, and the beta-lactamase activity was negative in all of these four sputum samples. Both beta-lactamase producing and non-producing strains were recovered in 5 of 6 sputum samples from which two to three microbes were isolated. The ratio of beta-lactamase-positive sputum sample was higher in patients who had received antibiotics than in those who had received no antibiotics. This difference was statistically significant (P < 0.025). It is possible that non-causative beta-lactamase-positive organisms enhance the pathogenicity of causative organisms that are beta-lactamase-negative.

    Original languageEnglish
    Pages (from-to)83-89
    Number of pages7
    JournalThe science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tōhoku Daigaku
    Volume38
    Issue number2-4
    Publication statusPublished - 1991 Dec

    ASJC Scopus subject areas

    • Medicine(all)

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