beta-blocker in hypertension

K. Takeuchi, N. Nushiro, K. Tsunoda, K. Abe

Research output: Contribution to journalReview articlepeer-review

Abstract

The beta-blockers are either nonselective and affect both beta 1- and beta 2-receptors, are relatively selective for the alpha 1 subclass, or are able to have activity against alpha-receptors. The ability to reduce blood pressure is very common among all beta-blockers, and beta-blockers are recommended for one of the first-line drugs in hypertension treatment by JNCV. beta-blockers should be used considering their pharmacological properties and potential side effects, according to the pathophysiological conditions involved. The superiority of beta-blocker to other types of antihypertensive drug has not yet been evidenced by larger scale clinical trials which have been carried out so far. To verify more precisely the usefulness of beta-blocker in hypertension treatment, more large scale clinical trials are required to be carried out. The fixed-dose combination of beta-blockers and calcium blockers appears to be more effective rather than that of beta-blockers and diuretics.

Original languageEnglish
Pages (from-to)2045-2054
Number of pages10
JournalNippon rinsho. Japanese journal of clinical medicine
Volume55
Issue number8
Publication statusPublished - 1997 Aug

ASJC Scopus subject areas

  • Medicine(all)

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