Benzophenones from an endophytic fungus, graphiopsis chlorocephala, from Paeonia lactiflora cultivated in the presence of an NAD+-dependent HDAC inhibitor

Teigo Asai, Sae Otsuki, Hiroaki Sakurai, Kouwa Yamashita, Tomoji Ozeki, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Graphiopsis chlorocephala was separated from the surface-sterilized healthy leaves of Paeonia lactiflora (Paeoniaceae) and cultivated with nicotinamide (an NAD+-dependent HDAC inhibitor). The culture conditions significantly enhanced secondary metabolite production in the fungus and led to the isolation of a structurally diverse set of new benzophenones, cephalanones A-F (1-6), and a known 2-(2,6-dihydroxy-4-methylbenzoyl)-6-hydroxybenzoic acid (7). The structures of 1-6 were determined from NMR data, single crystal X-ray diffraction, and chemical transformations.

Original languageEnglish
Pages (from-to)2058-2061
Number of pages4
JournalOrganic letters
Volume15
Issue number8
DOIs
Publication statusPublished - 2013 Apr 19

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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