Benefit of proactive therapy using topical steroid for atopic dermatitis - Effect of twice weekly topical application of 0.05% betamethasone butyrate propionate ointment - Effect o

Tadashi Terui, Yukiko Kiniwa, Atsuko Ashida, Ryuhei Okuyama, Maki Ozawa, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

Abstract

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease. To improve the patient's quality of life (QOL), preventing relapse after remission of skin eruption is one of the critical concerns. We investigated the effect of proactive (PRO) therapy using betamethasone butyrate propionate (BBP) ointment in moderate or severe AD patients. Following stabilization of skin eruption after daily application of BBP, patients were divided into two groups: the PRO group that received twice weekly topical application of BBP ointment based on daily topical application of a moisturizing agent and the control (CON) group that received topical monotherapy with a moisturizing agent. The effects on relapse prevention and QOLs were compared between the groups. Significant improvement in the scores of cutaneous findings from the baseline was observed in the PRO group after 8 weeks treatment or completion of the study. The scores of cutaneous findings after 4 weeks or 8 weeks treatment, or completion of the study were significantly lower in the PRO group than in the CON group. Based on the changes in daytime itching measures using the visual analog scale and Dermatology Life Quality Index, the symptoms were significantly improved in the PRO group after completion of the study. According to the weekly cumulative convergent maintenance duration of inflammation, significant prolongation was noted in the PRO group compared with in the CON group after 3 weeks treatment. The convergent maintenance rate was significantly higher in the PRO group than in the CON group. These results showed that PRO therapy using twice weekly topical application of BBP ointment was effective in moderate or severe AD patients for relapse prevention after stabilization of cutaneous inflammation and delayed relapse of inflammation. Thus, our results suggested that this PRO therapy is an effective topical strategy to reduce itching and improve patients' QOLs.

Original languageEnglish
Pages (from-to)598-605
Number of pages8
JournalNishinihon Journal of Dermatology
Volume76
Issue number6
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Dermatology

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