Beneficial effects of vitamin k status on glycemic regulation and diabetes mellitus: A mini-review

Hsin Jung Ho; Michio Komai; Hitoshi Shirakawa

doi:10.3390/nu12082485

Beneficial effects of vitamin k status on glycemic regulation and diabetes mellitus: A mini-review

Hsin Jung Ho, Michio Komai, Hitoshi Shirakawa

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Type 2 diabetes mellitus is a chronic disease that is characterized by hyperglycemia, insulin resistance, and dysfunctional insulin secretion. Glycemic control remains a crucial contributor to the progression of type 2 diabetes mellitus as well as the prevention or delay in the onset of diabetes-related complications. Vitamin K is a fat-soluble vitamin that plays an important role in the regulation of the glycemic status. Supplementation of vitamin K may reduce the risk of diabetes mellitus and improve insulin sensitivity. This mini-review summarizes the recent insights into the beneficial effects of vitamin K and its possible mechanism of action on insulin sensitivity and glycemic status, thereby suppressing the progression of diabetes mellitus.

Original language	English
Article number	2485
Pages (from-to)	1-16
Number of pages	16
Journal	Nutrients
Volume	12
Issue number	8
DOIs	https://doi.org/10.3390/nu12082485
Publication status	Published - 2020 Aug

Keywords

Diabetes mellitus
Glycemic status
Insulin sensitivity
Vitamin K

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu12082485

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abstract = "Type 2 diabetes mellitus is a chronic disease that is characterized by hyperglycemia, insulin resistance, and dysfunctional insulin secretion. Glycemic control remains a crucial contributor to the progression of type 2 diabetes mellitus as well as the prevention or delay in the onset of diabetes-related complications. Vitamin K is a fat-soluble vitamin that plays an important role in the regulation of the glycemic status. Supplementation of vitamin K may reduce the risk of diabetes mellitus and improve insulin sensitivity. This mini-review summarizes the recent insights into the beneficial effects of vitamin K and its possible mechanism of action on insulin sensitivity and glycemic status, thereby suppressing the progression of diabetes mellitus.",

keywords = "Diabetes mellitus, Glycemic status, Insulin sensitivity, Vitamin K",

author = "Ho, {Hsin Jung} and Michio Komai and Hitoshi Shirakawa",

note = "Funding Information: Funding: This work was partially supported by a Grant-in-aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS) to HS (#17H0314 and #20H02928) and by the JSPS Core-to-Core Program A (Advanced Research Networks) entitled “Establishment of international agricultural immunology research-core for a quantum improvement in food safety”. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Shirakawa, Hitoshi

N1 - Funding Information: Funding: This work was partially supported by a Grant-in-aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS) to HS (#17H0314 and #20H02928) and by the JSPS Core-to-Core Program A (Advanced Research Networks) entitled “Establishment of international agricultural immunology research-core for a quantum improvement in food safety”. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - Type 2 diabetes mellitus is a chronic disease that is characterized by hyperglycemia, insulin resistance, and dysfunctional insulin secretion. Glycemic control remains a crucial contributor to the progression of type 2 diabetes mellitus as well as the prevention or delay in the onset of diabetes-related complications. Vitamin K is a fat-soluble vitamin that plays an important role in the regulation of the glycemic status. Supplementation of vitamin K may reduce the risk of diabetes mellitus and improve insulin sensitivity. This mini-review summarizes the recent insights into the beneficial effects of vitamin K and its possible mechanism of action on insulin sensitivity and glycemic status, thereby suppressing the progression of diabetes mellitus.

AB - Type 2 diabetes mellitus is a chronic disease that is characterized by hyperglycemia, insulin resistance, and dysfunctional insulin secretion. Glycemic control remains a crucial contributor to the progression of type 2 diabetes mellitus as well as the prevention or delay in the onset of diabetes-related complications. Vitamin K is a fat-soluble vitamin that plays an important role in the regulation of the glycemic status. Supplementation of vitamin K may reduce the risk of diabetes mellitus and improve insulin sensitivity. This mini-review summarizes the recent insights into the beneficial effects of vitamin K and its possible mechanism of action on insulin sensitivity and glycemic status, thereby suppressing the progression of diabetes mellitus.

KW - Diabetes mellitus

KW - Glycemic status

KW - Insulin sensitivity

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Beneficial effects of vitamin k status on glycemic regulation and diabetes mellitus: A mini-review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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