Abstract
In the present study, to explore the beneficial effect of dietary galactoglycerolipids on the lower digestive tract environment, male BALB/c mice were fed a 5% wheat glycolipid, fiber-free diet, or the standard AIN diet for 3 wk. The wheat glycolipid composition was digalactosyldiacylglycerol 51.6%, ceramide monohexoside 6.6%, acylated sterylglucoside 3.4%, and other lipids 22.2% (mostly phospholipids). Cecum and colon weights and colonic crypt depth were significantly greater in the glycolipid-diet mice relative to groups fed the other two diets. Furthermore, in the cecum, propionate, butyrate, and total short-chain fatty acids, concentrations were significantly greater in the glycolipid-diet mice than others were, and correlated with the observed increased lower digestive tract (cecum and colon) weights and colonic crypt depth. The cecal lithocholic acid/deoxycholic acid ratio, a risk index for colorectal cancer, was significantly lower in the glycolipid-diet mice than in the other two dietary groups. These results suggest that the dietary supplementation of plant-source galactoglycerolipids may contribute to improving the lower digestive tract environment.
Original language | English |
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Pages (from-to) | 299-305 |
Number of pages | 7 |
Journal | Journal of nutritional science and vitaminology |
Volume | 47 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- Cecum
- Glycolipids
- Mice
- Secondary bile acids
- Short-chain fatty acids
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics