Beneficial effect of dietary wheat glycolipids on cecum short-chain fatty acid and secondary bile acid profiles in mice

T. Sugawara, T. Miyazawa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In the present study, to explore the beneficial effect of dietary galactoglycerolipids on the lower digestive tract environment, male BALB/c mice were fed a 5% wheat glycolipid, fiber-free diet, or the standard AIN diet for 3 wk. The wheat glycolipid composition was digalactosyldiacylglycerol 51.6%, ceramide monohexoside 6.6%, acylated sterylglucoside 3.4%, and other lipids 22.2% (mostly phospholipids). Cecum and colon weights and colonic crypt depth were significantly greater in the glycolipid-diet mice relative to groups fed the other two diets. Furthermore, in the cecum, propionate, butyrate, and total short-chain fatty acids, concentrations were significantly greater in the glycolipid-diet mice than others were, and correlated with the observed increased lower digestive tract (cecum and colon) weights and colonic crypt depth. The cecal lithocholic acid/deoxycholic acid ratio, a risk index for colorectal cancer, was significantly lower in the glycolipid-diet mice than in the other two dietary groups. These results suggest that the dietary supplementation of plant-source galactoglycerolipids may contribute to improving the lower digestive tract environment.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalJournal of nutritional science and vitaminology
Volume47
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Cecum
  • Glycolipids
  • Mice
  • Secondary bile acids
  • Short-chain fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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