Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia

Teruhito Okumura, Yoshinori Gonda, Koji Ioku, Masanobu Kamitakahara, Takatoshi Okuda, Ikuho Yonezawa, Hisashi Kurosawa, Izumi Asahina, Tohru Ikeda

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJournal of the Ceramic Society of Japan
Issue number1386
Publication statusPublished - 2011 Feb


  • Alkaline phosphatase
  • Beta-tricalcium phosphate
  • Bone substitute
  • Healing of bone defect
  • Hydrothermal route

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry


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