Basosquamous cell carcinoma developing from a renal transplantation recipient

Akira Tsukada; Taku Fujimura; Sadanori Furudate; Yumi Kambayashi; Akira Hashimoto; Setsuya Aiba

doi:10.1159/000345095

Basosquamous cell carcinoma developing from a renal transplantation recipient

Akira Tsukada, Taku Fujimura, Sadanori Furudate, Yumi Kambayashi, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a case of basosquamous cell carcinoma arising from a 52-year-old Japanese renal transplantation recipient (RTR). In the present case, we investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study suggests some of the possible mechanisms for the carcinogenesis of cutaneous malignancy in RTRs.

Original language	English
Pages (from-to)	227-232
Number of pages	6
Journal	Case Reports in Dermatology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1159/000345095
Publication status	Published - 2012 Apr 20

Keywords

Basosquamous cell carcinoma
CD163+ M2 macrophage
Carcinogenesis
Immunosuppressive cells

ASJC Scopus subject areas

Dermatology

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AU - Tsukada, Akira

AU - Fujimura, Taku

AU - Furudate, Sadanori

AU - Kambayashi, Yumi

AU - Hashimoto, Akira

AU - Aiba, Setsuya

PY - 2012/4/20

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N2 - We describe a case of basosquamous cell carcinoma arising from a 52-year-old Japanese renal transplantation recipient (RTR). In the present case, we investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study suggests some of the possible mechanisms for the carcinogenesis of cutaneous malignancy in RTRs.

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KW - Immunosuppressive cells

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