Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence

Kiyotake Ichizuka; Ryu Matsuoka; Hiroko Aoki; Junichi Hasegawa; Takashi Okai; Shin ichiro Umemura

doi:10.1007/s10396-016-0725-x

Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence

Kiyotake Ichizuka, Ryu Matsuoka, Hiroko Aoki, Junichi Hasegawa, Takashi Okai, Shin ichiro Umemura

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Purpose: The objective of the present study was to develop a high-intensity focused ultrasound (HIFU) transducer more suitable for clinical use in fetal therapy for twin reversed arterial perfusion (TRAP) sequence. Materials and methods: We created a cooling and degassed water-circulating-type HIFU treatment device. HIFU was applied to renal branch vessels in three rabbits. Sequential HIFU irradiation contains a trigger wave, heating wave, and rest time. The duration of HIFU application was 10 s/course. Targeting could be achieved by setting the imaging probe in the center and placing the HIFU beam and imaging ultrasonic wave on the same axis. Result: We confirmed under sequential HIFU irradiation with a total intensity of 1.94 kW/cm² (spatial average temporal average intensity) that the vein and artery were occluded in all three rabbits. Conclusion: Simultaneous occluding of the veins and arteries was confirmed with trigger waves and a resting phase using the HIFU transducer treatment device created for this study. Clinical application appears possible and may represent a promising option for fetal therapy involving TRAP sequence.

Original language	English
Pages (from-to)	487-492
Number of pages	6
Journal	Journal of Medical Ultrasonics
Volume	43
Issue number	4
DOIs	https://doi.org/10.1007/s10396-016-0725-x
Publication status	Published - 2016 Oct 1

Keywords

Fetal therapy
Flow occlusion
HIFU
TRAP sequence

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s10396-016-0725-x

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title = "Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence",

abstract = "Purpose: The objective of the present study was to develop a high-intensity focused ultrasound (HIFU) transducer more suitable for clinical use in fetal therapy for twin reversed arterial perfusion (TRAP) sequence. Materials and methods: We created a cooling and degassed water-circulating-type HIFU treatment device. HIFU was applied to renal branch vessels in three rabbits. Sequential HIFU irradiation contains a trigger wave, heating wave, and rest time. The duration of HIFU application was 10 s/course. Targeting could be achieved by setting the imaging probe in the center and placing the HIFU beam and imaging ultrasonic wave on the same axis. Result: We confirmed under sequential HIFU irradiation with a total intensity of 1.94 kW/cm2 (spatial average temporal average intensity) that the vein and artery were occluded in all three rabbits. Conclusion: Simultaneous occluding of the veins and arteries was confirmed with trigger waves and a resting phase using the HIFU transducer treatment device created for this study. Clinical application appears possible and may represent a promising option for fetal therapy involving TRAP sequence.",

keywords = "Fetal therapy, Flow occlusion, HIFU, TRAP sequence",

author = "Kiyotake Ichizuka and Ryu Matsuoka and Hiroko Aoki and Junichi Hasegawa and Takashi Okai and Umemura, {Shin ichiro}",

note = "Funding Information: This research was supported by the Research and Development Committee Program of the Japan Society of Ultrasonics in Medicine and by Grants-in-Aid for Scientific Research (C) (No. 25462576) from the Japan Society for the Promotion of Science. The authors would like to thank Shin Yoshizawa of Tohoku University and Kouhei Seo and Miki Kushima of Showa University for their technical support. Publisher Copyright: {\textcopyright} 2016, The Japan Society of Ultrasonics in Medicine.",

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doi = "10.1007/s10396-016-0725-x",

language = "English",

volume = "43",

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T1 - Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence

AU - Ichizuka, Kiyotake

AU - Matsuoka, Ryu

AU - Aoki, Hiroko

AU - Hasegawa, Junichi

AU - Okai, Takashi

AU - Umemura, Shin ichiro

N1 - Funding Information: This research was supported by the Research and Development Committee Program of the Japan Society of Ultrasonics in Medicine and by Grants-in-Aid for Scientific Research (C) (No. 25462576) from the Japan Society for the Promotion of Science. The authors would like to thank Shin Yoshizawa of Tohoku University and Kouhei Seo and Miki Kushima of Showa University for their technical support. Publisher Copyright: © 2016, The Japan Society of Ultrasonics in Medicine.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Purpose: The objective of the present study was to develop a high-intensity focused ultrasound (HIFU) transducer more suitable for clinical use in fetal therapy for twin reversed arterial perfusion (TRAP) sequence. Materials and methods: We created a cooling and degassed water-circulating-type HIFU treatment device. HIFU was applied to renal branch vessels in three rabbits. Sequential HIFU irradiation contains a trigger wave, heating wave, and rest time. The duration of HIFU application was 10 s/course. Targeting could be achieved by setting the imaging probe in the center and placing the HIFU beam and imaging ultrasonic wave on the same axis. Result: We confirmed under sequential HIFU irradiation with a total intensity of 1.94 kW/cm2 (spatial average temporal average intensity) that the vein and artery were occluded in all three rabbits. Conclusion: Simultaneous occluding of the veins and arteries was confirmed with trigger waves and a resting phase using the HIFU transducer treatment device created for this study. Clinical application appears possible and may represent a promising option for fetal therapy involving TRAP sequence.

AB - Purpose: The objective of the present study was to develop a high-intensity focused ultrasound (HIFU) transducer more suitable for clinical use in fetal therapy for twin reversed arterial perfusion (TRAP) sequence. Materials and methods: We created a cooling and degassed water-circulating-type HIFU treatment device. HIFU was applied to renal branch vessels in three rabbits. Sequential HIFU irradiation contains a trigger wave, heating wave, and rest time. The duration of HIFU application was 10 s/course. Targeting could be achieved by setting the imaging probe in the center and placing the HIFU beam and imaging ultrasonic wave on the same axis. Result: We confirmed under sequential HIFU irradiation with a total intensity of 1.94 kW/cm2 (spatial average temporal average intensity) that the vein and artery were occluded in all three rabbits. Conclusion: Simultaneous occluding of the veins and arteries was confirmed with trigger waves and a resting phase using the HIFU transducer treatment device created for this study. Clinical application appears possible and may represent a promising option for fetal therapy involving TRAP sequence.

KW - Fetal therapy

KW - Flow occlusion

KW - HIFU

KW - TRAP sequence

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Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence

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