Basic study of less invasive high-intensity focused ultrasound (HIFU) in fetal therapy for twin reversed arterial perfusion (TRAP) sequence

Kiyotake Ichizuka, Ryu Matsuoka, Hiroko Aoki, Junichi Hasegawa, Takashi Okai, Shin ichiro Umemura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: The objective of the present study was to develop a high-intensity focused ultrasound (HIFU) transducer more suitable for clinical use in fetal therapy for twin reversed arterial perfusion (TRAP) sequence. Materials and methods: We created a cooling and degassed water-circulating-type HIFU treatment device. HIFU was applied to renal branch vessels in three rabbits. Sequential HIFU irradiation contains a trigger wave, heating wave, and rest time. The duration of HIFU application was 10 s/course. Targeting could be achieved by setting the imaging probe in the center and placing the HIFU beam and imaging ultrasonic wave on the same axis. Result: We confirmed under sequential HIFU irradiation with a total intensity of 1.94 kW/cm2 (spatial average temporal average intensity) that the vein and artery were occluded in all three rabbits. Conclusion: Simultaneous occluding of the veins and arteries was confirmed with trigger waves and a resting phase using the HIFU transducer treatment device created for this study. Clinical application appears possible and may represent a promising option for fetal therapy involving TRAP sequence.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalJournal of Medical Ultrasonics
Volume43
Issue number4
DOIs
Publication statusPublished - 2016 Oct 1

Keywords

  • Fetal therapy
  • Flow occlusion
  • HIFU
  • TRAP sequence

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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