TY - JOUR
T1 - Basic and clinical studies on cefetamet pivoxil and its efficacy in respiratory tract infections
AU - Aonuma, Seiichi
AU - Oizumi, Kotaro
AU - Watanabe, Akira
AU - Honda, Yoshihiro
AU - Tokue, Yutaka
AU - Kitamura, Naoto
AU - Shoji, Satoru
AU - Motomiya, Masakichi
AU - Konno, Kiyoshi
AU - Nagai, Kosaku
PY - 1990/1/1
Y1 - 1990/1/1
N2 - We examined the in vitro antimicrobial activity of cefetamet (CEMT), a metabolite of the orally absorbed cefetamet pivoxil (CEMT-PI), a newly developed cephem antibiotic, by the broth dilution methed using the MIC-2000 system. Minimum inhibitory concentrations (MICs) of CEMT against 120 clinical isolates were compared with those of cefixime (CFIX) and cefaclor (CCL). Against Staphylococcus aureus, CEMT was less active than CFIX and CCL, but against Escherichia coli, Klebsiella pneumoniae and Serratia marcescens it was much more active than CCL, though less active than CFIX. Against Enterobacter cloacae it was as active as CFIX. Eight patients suffering from respiratory tract infections were given 500mg or 1, 000mg of CEMT-PI orally once a day for 3∼8 days. Clinical response was good in seven and fair in one patient Wooziness was observed in one patient.
AB - We examined the in vitro antimicrobial activity of cefetamet (CEMT), a metabolite of the orally absorbed cefetamet pivoxil (CEMT-PI), a newly developed cephem antibiotic, by the broth dilution methed using the MIC-2000 system. Minimum inhibitory concentrations (MICs) of CEMT against 120 clinical isolates were compared with those of cefixime (CFIX) and cefaclor (CCL). Against Staphylococcus aureus, CEMT was less active than CFIX and CCL, but against Escherichia coli, Klebsiella pneumoniae and Serratia marcescens it was much more active than CCL, though less active than CFIX. Against Enterobacter cloacae it was as active as CFIX. Eight patients suffering from respiratory tract infections were given 500mg or 1, 000mg of CEMT-PI orally once a day for 3∼8 days. Clinical response was good in seven and fair in one patient Wooziness was observed in one patient.
KW - CEMT-PI
KW - Cefetamet pivoxil
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U2 - 10.11250/chemotherapy1953.38.Supplement1_106
DO - 10.11250/chemotherapy1953.38.Supplement1_106
M3 - Article
AN - SCOPUS:0025609526
VL - 38
SP - 106
EP - 109
JO - CHEMOTHERAPY
JF - CHEMOTHERAPY
SN - 0009-3165
ER -
