Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan

T. Nishimura, M. Takeda, K. Shinosaki, T. Nishikawa, Y. Nakamura, Y. Yoshida, H. Sasaki, H. Arai, S. Hirai, M. Shouji, K. Isse, K. Tanaka, M. Hamamoto, H. Yamamoto, T. Matsubayashi, K. Nakashima, K. Urakami, Y. Adachi, S. Nakamura, H. TojiH. Yoshida

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The fundamental reagent capability and clinical significance of ApoE gene typing has been investigated. The result of each test shows that the reagent capability satisfied the expected standard. Four-hundred thirty-nine samples classified into three groups (Alzheimer's disease (AD), other types of dementia and nondementia) were measured to examine the clinical significance. The rate of ε4 genotype of each group was 31.5%, 14.6%, 10.4%, respectively. The AD group had a higher rate than the other groups (p < 0.001). The measurement of ApoE genotype is suggested to be useful as one of the guidelines in the diagnosis of AD.

Original languageEnglish
Pages (from-to)793-799
Number of pages7
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume20
Issue number9
Publication statusPublished - 1998

Keywords

  • Alzheimer's disease
  • ApoE genotype
  • ApoE4
  • Dementia
  • LiPA

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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