The fundamental reagent capability and clinical significance of ApoE gene typing has been investigated. The result of each test shows that the reagent capability satisfied the expected standard. Four-hundred thirty-nine samples classified into three groups (Alzheimer's disease (AD), other types of dementia and nondementia) were measured to examine the clinical significance. The rate of ε4 genotype of each group was 31.5%, 14.6%, 10.4%, respectively. The AD group had a higher rate than the other groups (p < 0.001). The measurement of ApoE genotype is suggested to be useful as one of the guidelines in the diagnosis of AD.
|Number of pages||7|
|Journal||Methods and Findings in Experimental and Clinical Pharmacology|
|Publication status||Published - 1998|
- Alzheimer's disease
- ApoE genotype
ASJC Scopus subject areas
- Pharmacology (medical)