Basic and clinical studies on 7432-S

Yuuichi Inoue, Yasuharu Masuyama, Yasumasa Dotsu, Mitsuo Kaku, Naofumi Suyama, Tosiaki Hayashi, Shiceru Kohno, Keizo Yamaguchi, Masaki Hirota, Kohei Hara, Kazuo Noda, Chikako Mochida, Kazuyuki Sugawara, Kouichi Watanabe, Tsuneo Tsutsumi, Hiroshi Soda, Yoshito Tanaka, Masafumi Hayashida

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We carried out laboratory and clinical studies on 7432-S, a newly developed oral cephem antibiotic. The following results were obtained. 1) Antibacterial activity The antibacterial activity of 7432-S was examined by the serial microbroth dilution method using the MIC-2000 system (Dynateck Co.). The minimum inhibitory concentration (MICs) of 7432-S against 29 standard strains and 473 clinical isolates of 14 different species were compared with those of cefixime (CFIX), cephalexin (CEX), cefaclor (CCL), amoxicillin (AMPC) and ofloxacin (OFLX). The antimicrobial activity of 7432-S against Gram-negative bacilli was excellent, particularly against enterobacteriaceae, but it was weak against Gram-positive cocci. 2) Clinical efficacy and adverse reactions. Twenty-three patients with respiratory infection (chronic bronchitis 16, pneumonia 2, bronchiectasis 1, diffuse panbronchiolitis 1, pulmonary fibrosis with infection 1, acute bronchitis 1, pneumoconiosis with infection 1) were treated with 7432-S. The overall efficacy rate was 61.9%(excellent 2, good 11, fair 4, poor 4, unevaluable 2). No significant side effect was observed. One patient, however, showed epigastralgia. A transient increase in eosinophils, and elevation of GOT, GPT and ALP was noted in 3 patients.

Original languageEnglish
Pages (from-to)285-297
Number of pages13
JournalChemotherapy
Volume37
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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