Basal cell carcinoma with spontaneous regression: A case report and immunohistochemical study

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10 Citations (Scopus)

Abstract

Spontaneous regression of basal cell carcinoma (BCC) is rare, and characterized by various tumor-infiltrating lymphocytes (TILs) in the tumor. A previous report suggested that these infiltrated lymphocytes consist of type 1 helper T cells, but no detailed phenotypical analysis of other TILs has been demonstrated yet. In this report, we describe an 84-year-old Japanese patient with spontaneous regression of BCC. In the present case, we investigated the immunohistochemical profiles of TILs, not only focusing on the cytotoxic T cells, but the profiles of immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study sheds light on the immunological mechanisms of tumor rejection in human BCC.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalCase Reports in Dermatology
Volume4
Issue number2
DOIs
Publication statusPublished - 2012 May
Externally publishedYes

Keywords

  • Basal cell carcinoma
  • Spontaneous regression
  • Tumor-infiltrating lymphocytes

ASJC Scopus subject areas

  • Dermatology

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