Basal cell carcinoma arising from xeroderma pigmentosum: A case report and an immunohistochemical study

Sadanori Furudate, Taku Fujimura, Gen Ichi Tojo, Takahiro Haga, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163+ M2 macrophages, together with Foxp3 + regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was al-so detected in the CD163+ M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalCase Reports in Dermatology
Volume5
Issue number1
DOIs
Publication statusPublished - 2013 Jan

Keywords

  • Basal cell carcinoma
  • CD163
  • Foxp3
  • M2 macrophages
  • Xeroderma pigmentosum

ASJC Scopus subject areas

  • Dermatology

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