Bardet-Biedl syndrome type 3 in an Iranian family: Clinical study and confirmation of disease localization

Mohsen Ghadami, Hiro Aki Tomita, Mohammad Taghi Najafi, Elia Damavandi, Mohammad Sadegh Farahvash, Koki Yamada, Keyvan Majidzadeh-A, Norio Niikawa

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Bardet-Biedl syndrome (BBS) is a group of autosomal recessive MCA/MR syndromes characterized by pigmentary retinopathy, postaxial polydactyly, hypogenitalism, obesity, and mental retardation. Five BBS loci have been identified; among them, BBS type 1 (BBS1) and type 3 (BBS3) are most common and most rare, respectively. We encountered an Iranian family that had seven affected members. All patients had a history of mild to severe obesity, but it was reversible in some patients by caloric restriction and exercise. All patients had pigmentary retinopathy, beginning as night blindness in early childhood and progressing toward severe impairment of vision by the end of the second decade. Polydactyly varied in limb distribution, ranging from four-limb involvement to random involvement or even to nonaffectedness. Six of the seven patients were not mentally retarded. Although kidney anomaly or an adrenal mass was present in two patients, the fact that one patient had seven children rules out reproductive dysfunction. Linkage analysis with microsatellite markers showed that the disease in the family was assigned to a region around marker loci at 3p13-p12 (maximum LOD score = 4.15 and recombination fraction θ = 0, at D3S1603 microsatellite marker), to which the BBS3 locus has been mapped. Haplotype analysis did not reduce the extent of the previously reported critical region of BBS3. A comparison of clinical manifestations of our patients with those of previously reported BBS3 patients did not support any type-specific phenotypes, though manifestations in our patients are similar to those in BBS3 patients of a family in Newfoundland. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)433-437
Number of pages5
JournalAmerican journal of medical genetics
Volume94
Issue number5
DOIs
Publication statusPublished - 2000 Oct 23
Externally publishedYes

Keywords

  • Autosomal recessive
  • Bardet-Biedl syndrome type 3
  • Iranian family
  • Linkage analysis
  • Mental retardation
  • Obesity
  • Pigmentary retinopathy
  • Polydactyly, hypogenitalism

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Bardet-Biedl syndrome type 3 in an Iranian family: Clinical study and confirmation of disease localization'. Together they form a unique fingerprint.

Cite this