TY - JOUR
T1 - Bacillus subtilis DprA recruits RecA onto single-stranded DNA and mediates annealing of complementary strands coated by SsbB and SsbA
AU - Yadav, Tribhuwan
AU - Carrasco, Begoña
AU - Hejna, James
AU - Suzuki, Yuki
AU - Takeyasu, Kunio
AU - Alonso, Juan C.
PY - 2013/8/2
Y1 - 2013/8/2
N2 - Background: Different mediators assist RecA to catalyze genetic recombination. Results: DprA facilitates the displacement of both SSBs (SsbB and SsbA), increases RecA nucleation onto SSB-coated ssDNA, and mediates DNA strand annealing. Conclusion: DprA facilitates RecA-mediated strand exchange and anneals complementary strands coated by an SSB protein. Significance: RecA-dependent chromosomal transformation and RecA-independent plasmid transformation require the competence-induced DprA mediator.
AB - Background: Different mediators assist RecA to catalyze genetic recombination. Results: DprA facilitates the displacement of both SSBs (SsbB and SsbA), increases RecA nucleation onto SSB-coated ssDNA, and mediates DNA strand annealing. Conclusion: DprA facilitates RecA-mediated strand exchange and anneals complementary strands coated by an SSB protein. Significance: RecA-dependent chromosomal transformation and RecA-independent plasmid transformation require the competence-induced DprA mediator.
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U2 - 10.1074/jbc.M113.478347
DO - 10.1074/jbc.M113.478347
M3 - Article
C2 - 23779106
AN - SCOPUS:84881257566
VL - 288
SP - 22437
EP - 22450
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 31
ER -