BACH transcription factors in innate and adaptive immunity

Kazuhiko Igarashi, Tomohiro Kurosaki, Rahul Roychoudhuri

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)

Abstract

BTB and CNC homology (BACH) proteins are transcriptional repressors of the basic region leucine zipper (bZIP) transcription factor family. Recent studies indicate widespread roles of BACH proteins in controlling the development and function of the innate and adaptive immune systems, including the differentiation of effector and memory cells of the B and T cell lineages, CD4 + regulatory T cells and macrophages. Here, we emphasize similarities at a molecular level in the cell-type-specific activities of BACH factors, proposing that competitive interactions of BACH proteins with transcriptional activators of the bZIP family form a common mechanistic theme underlying their diverse actions. The findings contribute to a general understanding of how transcriptional repressors shape lineage commitment and cell-type-specific functions through repression of alternative lineage programmes.

Original languageEnglish
Pages (from-to)437-450
Number of pages14
JournalNature Reviews Immunology
Volume17
Issue number7
DOIs
Publication statusPublished - 2017 Jul 1
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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