B-raf, a new member of the raf family, is activated by DNA rearrangement.

S. Ikawa, M. Fukui, Y. Ueyama, N. Tamaoki, T. Yamamoto, K. Toyoshima

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)

Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

Original languageEnglish
Pages (from-to)2651-2654
Number of pages4
JournalMolecular and cellular biology
Volume8
Issue number6
DOIs
Publication statusPublished - 1988 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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