Axonal Degeneration of the Peripheral Nerves and Postganglionic Anhidrosis in a Patient with Multiple Sclerosis

Hiroshi Saito, Kazuo Kobayashi, Hiroshi Mochizuki, Tomonori Ishii

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

SAITO, H., KOBAYASHI, K., MOCHIZUKI, H. and ISHII, T. Axonal Degeneration of the Peripheral Nerves and Postganglionic Anhidrosis in a Patient with Multiple Sclerosis. Tohoku J. Exp. Med., 1990, 162 (3), 279-291 — A 36-year-old woman had, since the age of 24, numerous episodes of visual loss and spinal symptoms and signs at various levels, and was diagnosed as multiple sclerosis(MS). CSF myelin-basic-protein was increased. Neurological and electrophysiological investigations suggested the peripheral nerve involvement. Sural nerve biopsy performed about six years after the onset, revealed severe loss of both myelinated and unmyelinated fibers. Subsequently, histamine skin reaction was defective in the lower limbs. Tests on sudomotor and pupillary functions indicated deficits of both central and postganglionic sympathetic systems. Though we could not detect causative factors for the peripheral nerve lesions, our patient appears to be the first documented case of MS associated with axonal degeneration of the peripheral somatic and autonomic nervous systems. — multiple sclerosis ; peripheral nerve ; axonal degeneration ; postganglionic lesions.

Original languageEnglish
Pages (from-to)279-291
Number of pages13
JournalTohoku Journal of Experimental Medicine
Volume162
Issue number3
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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