Axially chiral guanidine as enantioselective base catalyst for 1,4-addition reaction of 1,3-dicarbonyl compounds with conjugated nitroalkenes

Masahiro Terada, Hitoshi Ube, Yusuke Yaguchi

Research output: Contribution to journalArticlepeer-review

228 Citations (Scopus)

Abstract

A new strategy for designing chiral guanidine molecules is presented, which features the introduction of an axially chiral binaphthyl backbone. The axially chiral guanidine catalysts thus developed facilitated the highly enantioselective 1,4-addition reaction of 1,3-dicarbonyl compounds with a broad range of conjugated nitroalkenes and showed extremely high catalytic activity.

Original languageEnglish
Pages (from-to)1454-1455
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number5
DOIs
Publication statusPublished - 2006 Feb 8

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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