Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages

Kevin Moreau, Sandra Lacas-Gervais, Naonobu Fujita, Florent Sebbane, Tamotsu Yoshimori, Michel Simonet, Frank Lafont

    Research output: Contribution to journalArticle

    49 Citations (Scopus)

    Abstract

    Summary: Yersinia pseudotuberculosis is able to replicate inside macrophages. However, the intracellular trafficking of the pathogen after its entry into the macrophage remains poorly understood. Using in vitro infected bone marrow-derived macrophages, we show that Y. pseudotuberculosis activates the autophagy pathway. Host cell autophagosomes subverted by bacteria do not become acidified and sustain bacteria replication. Moreover, we report that autophagy inhibition correlated with bacterial trafficking inside an acidic compartment. This study indicates that Y. pseudotuberculosis hijacks the autophagy pathway for its replication and also opens up new opportunities for deciphering the molecular basis of the host cell signalling response to intracellular Yersinia infection.

    Original languageEnglish
    Pages (from-to)1108-1123
    Number of pages16
    JournalCellular Microbiology
    Volume12
    Issue number8
    DOIs
    Publication statusPublished - 2010 Aug

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Virology

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  • Cite this

    Moreau, K., Lacas-Gervais, S., Fujita, N., Sebbane, F., Yoshimori, T., Simonet, M., & Lafont, F. (2010). Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages. Cellular Microbiology, 12(8), 1108-1123. https://doi.org/10.1111/j.1462-5822.2010.01456.x