By the use of the vehicle, function of the Human body has been expanded more and more in the history. If human body will be connected to the vehicle, the vehicle will become a part of a human body. In the previous reports, several investigators have been studying about the man-machine interface. Furthermore, we added the therapeutic effect for the autonomic nervous system during driving in this study. ECG and pulse wave recording system was added to the handle and drive console in the experimental system. Air pressure sensors to detect the respiration and aortic pulse wave were inserted into the drive seat. By the evaluation of the ECG and pulse wave, we can evaluate the circulation dynamics, and furthermore, we can evaluate the pulse wave velocity and fluctuations in hemodynamic derivatives. By the use of this information, several kinds of Aroma, Massage to the Acu-point or the Moxibustion were added to the driver. So, the automobile can control the autonomic nerve condition during driving. After ethical committee allowance we evaluated the effect of aroma and moxibustion therapy on driver. Hemodynamics, HRV and baroreflex system was tended to altered depending of the kinds of Aroma, acupuncture point stimulation with massage and moxibustion. These results suggest that vehicle can become artificial automatic nerve controller in future.