Automated synthesis system with computer control for the production of [1-11C]fatty acids

Toshihiro Takahashi; Tatsuo Ido; Ren Iwata; Kentaro Hatano; Hiroaki Nakanishi; Makoto Shinohara; Shigenori Iida

doi:10.1016/0883-2889(88)90054-8

Automated synthesis system with computer control for the production of [1-¹¹C]fatty acids

Toshihiro Takahashi, Tatsuo Ido, Ren Iwata, Kentaro Hatano, Hiroaki Nakanishi, Makoto Shinohara, Shigenori Iida

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

To accommodate the increasing need for [1-¹¹C]fatty acids for use in routine medical studies and the large amounts of radioactivity required, a more advanced automated synthesis system for the preparation of [1-¹¹C]fatty acids has been constructed. The synthesis of [1-¹¹C]fatty acids has been completely automated using a new separation unit (isobaric Sepaltor) for the extraction procedure, which had caused some difficulties with automation. The yield of [1-¹¹C]palmitic acid was 20-30 mCi, and that of 3-methyl [1-¹¹C]heptadecanoic acid was 2-7 mCi. The time required for the synthesis was less than 30 min from the start of the ¹¹CO₂ trapping. This system has been used for more than 20 preparations of [1-¹¹C]palmitic acid and more than 20 preparations of 3-methyl [1-¹¹C]heptadecanoic acid.

Original language	English
Pages (from-to)	659-665
Number of pages	7
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	39
Issue number	7
DOIs	https://doi.org/10.1016/0883-2889(88)90054-8
Publication status	Published - 1988 Jan 1

ASJC Scopus subject areas

Radiation
Engineering(all)

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Automated synthesis system with computer control for the production of [1-¹¹C]fatty acids. / Takahashi, Toshihiro; Ido, Tatsuo; Iwata, Ren; Hatano, Kentaro; Nakanishi, Hiroaki; Shinohara, Makoto; Iida, Shigenori.

In: International Journal of Radiation Applications and Instrumentation. Part, Vol. 39, No. 7, 01.01.1988, p. 659-665.

Research output: Contribution to journal › Article › peer-review

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abstract = "To accommodate the increasing need for [1-11C]fatty acids for use in routine medical studies and the large amounts of radioactivity required, a more advanced automated synthesis system for the preparation of [1-11C]fatty acids has been constructed. The synthesis of [1-11C]fatty acids has been completely automated using a new separation unit (isobaric Sepaltor) for the extraction procedure, which had caused some difficulties with automation. The yield of [1-11C]palmitic acid was 20-30 mCi, and that of 3-methyl [1-11C]heptadecanoic acid was 2-7 mCi. The time required for the synthesis was less than 30 min from the start of the 11CO2 trapping. This system has been used for more than 20 preparations of [1-11C]palmitic acid and more than 20 preparations of 3-methyl [1-11C]heptadecanoic acid.",

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AU - Nakanishi, Hiroaki

AU - Shinohara, Makoto

AU - Iida, Shigenori

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