TY - JOUR
T1 - Automated synthesis system with computer control for the production of [1-11C]fatty acids
AU - Takahashi, Toshihiro
AU - Ido, Tatsuo
AU - Iwata, Ren
AU - Hatano, Kentaro
AU - Nakanishi, Hiroaki
AU - Shinohara, Makoto
AU - Iida, Shigenori
PY - 1988/1/1
Y1 - 1988/1/1
N2 - To accommodate the increasing need for [1-11C]fatty acids for use in routine medical studies and the large amounts of radioactivity required, a more advanced automated synthesis system for the preparation of [1-11C]fatty acids has been constructed. The synthesis of [1-11C]fatty acids has been completely automated using a new separation unit (isobaric Sepaltor) for the extraction procedure, which had caused some difficulties with automation. The yield of [1-11C]palmitic acid was 20-30 mCi, and that of 3-methyl [1-11C]heptadecanoic acid was 2-7 mCi. The time required for the synthesis was less than 30 min from the start of the 11CO2 trapping. This system has been used for more than 20 preparations of [1-11C]palmitic acid and more than 20 preparations of 3-methyl [1-11C]heptadecanoic acid.
AB - To accommodate the increasing need for [1-11C]fatty acids for use in routine medical studies and the large amounts of radioactivity required, a more advanced automated synthesis system for the preparation of [1-11C]fatty acids has been constructed. The synthesis of [1-11C]fatty acids has been completely automated using a new separation unit (isobaric Sepaltor) for the extraction procedure, which had caused some difficulties with automation. The yield of [1-11C]palmitic acid was 20-30 mCi, and that of 3-methyl [1-11C]heptadecanoic acid was 2-7 mCi. The time required for the synthesis was less than 30 min from the start of the 11CO2 trapping. This system has been used for more than 20 preparations of [1-11C]palmitic acid and more than 20 preparations of 3-methyl [1-11C]heptadecanoic acid.
UR - http://www.scopus.com/inward/record.url?scp=0023844728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023844728&partnerID=8YFLogxK
U2 - 10.1016/0883-2889(88)90054-8
DO - 10.1016/0883-2889(88)90054-8
M3 - Article
C2 - 2844700
AN - SCOPUS:0023844728
VL - 39
SP - 659
EP - 665
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 7
ER -