Automated synthesis system with computer control for the production of [1-11C]fatty acids

Toshihiro Takahashi, Tatsuo Ido, Ren Iwata, Kentaro Hatano, Hiroaki Nakanishi, Makoto Shinohara, Shigenori Iida

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

To accommodate the increasing need for [1-11C]fatty acids for use in routine medical studies and the large amounts of radioactivity required, a more advanced automated synthesis system for the preparation of [1-11C]fatty acids has been constructed. The synthesis of [1-11C]fatty acids has been completely automated using a new separation unit (isobaric Sepaltor) for the extraction procedure, which had caused some difficulties with automation. The yield of [1-11C]palmitic acid was 20-30 mCi, and that of 3-methyl [1-11C]heptadecanoic acid was 2-7 mCi. The time required for the synthesis was less than 30 min from the start of the 11CO2 trapping. This system has been used for more than 20 preparations of [1-11C]palmitic acid and more than 20 preparations of 3-methyl [1-11C]heptadecanoic acid.

Original languageEnglish
Pages (from-to)659-665
Number of pages7
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume39
Issue number7
DOIs
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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