Automated synthesis system for production of 2-deoxy-2-[18F]fluoro-D-glucose with computer control

Iwata Ren Iwata, Ido Tatsuo Ido, Takahashi Toshihiro Takahashi, Monma Minoru Monma

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

An automated synthesis system for the production of 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) has been developed. The system has been designed to be as convenient as possible for routine clinical use, and the whole synthetic procedure ranging from target irridiation to collection of a 18FDG solution has been completely automated by using a mucomputer as a controller and sensors of temperature, pressure, radioactivity and liquid level. This system provides 20-30 mCi of 18FDG in a sterile and pyrogen-free aqueous solution with a high radiochemical purity (over 98%) within 80 min after the 2-h irradiation with a current of 12 μA. The present automated synthesis system is suitable for routine production of 18FDG.

Original languageEnglish
Pages (from-to)445-454
Number of pages10
JournalThe International Journal Of Applied Radiation And Isotopes
Volume35
Issue number6
DOIs
Publication statusPublished - 1984 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Radiation
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging

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