Automated synthesis system for production of 2-deoxy-2-[18F]fluoro-D-glucose with computer control

Iwata Ren Iwata, Ido Tatsuo Ido, Takahashi Toshihiro Takahashi, Monma Minoru Monma

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)

    Abstract

    An automated synthesis system for the production of 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) has been developed. The system has been designed to be as convenient as possible for routine clinical use, and the whole synthetic procedure ranging from target irridiation to collection of a 18FDG solution has been completely automated by using a mucomputer as a controller and sensors of temperature, pressure, radioactivity and liquid level. This system provides 20-30 mCi of 18FDG in a sterile and pyrogen-free aqueous solution with a high radiochemical purity (over 98%) within 80 min after the 2-h irradiation with a current of 12 μA. The present automated synthesis system is suitable for routine production of 18FDG.

    Original languageEnglish
    Pages (from-to)445-454
    Number of pages10
    JournalThe International Journal Of Applied Radiation And Isotopes
    Volume35
    Issue number6
    DOIs
    Publication statusPublished - 1984 Jun

    ASJC Scopus subject areas

    • Radiation
    • Nuclear Energy and Engineering
    • Radiology Nuclear Medicine and imaging

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