Automated synthesis of 5-[18F]fluoro-2′-deoxyuridine

Kiichi Ishiwata, Minoru Monma, Ren Iwata, Tatsuo Ido

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    An automated synthesis system for the production of 5-[18F]fluoro-2′-deoxyuridine ([18F]FdUrd) has been developed for routine clinical use. The reaction process consists of addition of 18F2 to 3,5-di-O-acetyl-2′-deoxyuridine, hydrolysis of 18F-adduct and purification of [18F]FdUrd on tandem columns of ion retardation resin and alumina. These procedures are controlled by a microcomputer. The system provides about 30 mCi of [18F]FdUrd in a sterile and pyrogen-free aqueous solution with a radiochemical yield of 20% and a radiochemical purity of over 98% within 60 min after the 60-min irradiation with a current of 12 μA.

    Original languageEnglish
    Pages (from-to)467-473
    Number of pages7
    JournalInternational Journal of Radiation Applications and Instrumentation. Part
    Volume38
    Issue number6
    DOIs
    Publication statusPublished - 1987 Jan 1

    ASJC Scopus subject areas

    • Radiation
    • Engineering(all)

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