Automated synthesis of 5-[18F]fluoro-2′-deoxyuridine

Kiichi Ishiwata; Minoru Monma; Ren Iwata; Tatsuo Ido

doi:10.1016/0883-2889(87)90101-8

Automated synthesis of 5-[¹⁸F]fluoro-2′-deoxyuridine

Kiichi Ishiwata, Minoru Monma, Ren Iwata, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

An automated synthesis system for the production of 5-[¹⁸F]fluoro-2′-deoxyuridine ([¹⁸F]FdUrd) has been developed for routine clinical use. The reaction process consists of addition of ¹⁸F₂ to 3,5-di-O-acetyl-2′-deoxyuridine, hydrolysis of ¹⁸F-adduct and purification of [¹⁸F]FdUrd on tandem columns of ion retardation resin and alumina. These procedures are controlled by a microcomputer. The system provides about 30 mCi of [¹⁸F]FdUrd in a sterile and pyrogen-free aqueous solution with a radiochemical yield of 20% and a radiochemical purity of over 98% within 60 min after the 60-min irradiation with a current of 12 μA.

Original language	English
Pages (from-to)	467-473
Number of pages	7
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/0883-2889(87)90101-8
Publication status	Published - 1987 Jan 1

ASJC Scopus subject areas

Radiation
Engineering(all)

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title = "Automated synthesis of 5-[18F]fluoro-2′-deoxyuridine",

abstract = "An automated synthesis system for the production of 5-[18F]fluoro-2′-deoxyuridine ([18F]FdUrd) has been developed for routine clinical use. The reaction process consists of addition of 18F2 to 3,5-di-O-acetyl-2′-deoxyuridine, hydrolysis of 18F-adduct and purification of [18F]FdUrd on tandem columns of ion retardation resin and alumina. These procedures are controlled by a microcomputer. The system provides about 30 mCi of [18F]FdUrd in a sterile and pyrogen-free aqueous solution with a radiochemical yield of 20% and a radiochemical purity of over 98% within 60 min after the 60-min irradiation with a current of 12 μA.",

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AU - Ishiwata, Kiichi

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AU - Iwata, Ren

AU - Ido, Tatsuo

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AB - An automated synthesis system for the production of 5-[18F]fluoro-2′-deoxyuridine ([18F]FdUrd) has been developed for routine clinical use. The reaction process consists of addition of 18F2 to 3,5-di-O-acetyl-2′-deoxyuridine, hydrolysis of 18F-adduct and purification of [18F]FdUrd on tandem columns of ion retardation resin and alumina. These procedures are controlled by a microcomputer. The system provides about 30 mCi of [18F]FdUrd in a sterile and pyrogen-free aqueous solution with a radiochemical yield of 20% and a radiochemical purity of over 98% within 60 min after the 60-min irradiation with a current of 12 μA.

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