Abstract
An automated synthesis system for the production of 5-[18F]fluoro-2′-deoxyuridine ([18F]FdUrd) has been developed for routine clinical use. The reaction process consists of addition of 18F2 to 3,5-di-O-acetyl-2′-deoxyuridine, hydrolysis of 18F-adduct and purification of [18F]FdUrd on tandem columns of ion retardation resin and alumina. These procedures are controlled by a microcomputer. The system provides about 30 mCi of [18F]FdUrd in a sterile and pyrogen-free aqueous solution with a radiochemical yield of 20% and a radiochemical purity of over 98% within 60 min after the 60-min irradiation with a current of 12 μA.
Original language | English |
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Pages (from-to) | 467-473 |
Number of pages | 7 |
Journal | International Journal of Radiation Applications and Instrumentation. Part |
Volume | 38 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1987 Jan 1 |
ASJC Scopus subject areas
- Radiation
- Engineering(all)