Automated injection of a radioactive sample for preparative HPLC with feedback control

Ren Iwata; Shigeki Yamazaki; Tatsuo Ido

doi:10.1016/0883-2889(90)90211-X

Automated injection of a radioactive sample for preparative HPLC with feedback control

Ren Iwata, Shigeki Yamazaki, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The injection of a radioactive reaction mixture into a preparative HPLC column has been automated with computer control for rapid purification of routinely prepared positron emitting radiopharmaceuticals. Using pneumatic valves, a motor-driven pump and a liquid level sensor, two intelligent injection methods for the automation were compared with regard to efficient and rapid sample loading into a 2 mL loop of the 6-way valve. One, a precise but rather slow method, was demonstrated to be suitable for purification of ¹⁸F-radiopharmaceuticals, while the other, due to its rapid operation, was more suitable for ¹¹C-radiopharmaceuticals. A sample volume of approx 0.5 mL can be injected onto a preparative HPLC column in over 90% efficiency with the present automated system.

Original language	English
Pages (from-to)	1225-1227
Number of pages	3
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	41
Issue number	12
DOIs	https://doi.org/10.1016/0883-2889(90)90211-X
Publication status	Published - 1990

ASJC Scopus subject areas

Radiation
Engineering(all)

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abstract = "The injection of a radioactive reaction mixture into a preparative HPLC column has been automated with computer control for rapid purification of routinely prepared positron emitting radiopharmaceuticals. Using pneumatic valves, a motor-driven pump and a liquid level sensor, two intelligent injection methods for the automation were compared with regard to efficient and rapid sample loading into a 2 mL loop of the 6-way valve. One, a precise but rather slow method, was demonstrated to be suitable for purification of 18F-radiopharmaceuticals, while the other, due to its rapid operation, was more suitable for 11C-radiopharmaceuticals. A sample volume of approx 0.5 mL can be injected onto a preparative HPLC column in over 90% efficiency with the present automated system.",

author = "Ren Iwata and Shigeki Yamazaki and Tatsuo Ido",

year = "1990",

doi = "10.1016/0883-2889(90)90211-X",

language = "English",

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T1 - Automated injection of a radioactive sample for preparative HPLC with feedback control

AU - Iwata, Ren

AU - Yamazaki, Shigeki

AU - Ido, Tatsuo

PY - 1990

Y1 - 1990

N2 - The injection of a radioactive reaction mixture into a preparative HPLC column has been automated with computer control for rapid purification of routinely prepared positron emitting radiopharmaceuticals. Using pneumatic valves, a motor-driven pump and a liquid level sensor, two intelligent injection methods for the automation were compared with regard to efficient and rapid sample loading into a 2 mL loop of the 6-way valve. One, a precise but rather slow method, was demonstrated to be suitable for purification of 18F-radiopharmaceuticals, while the other, due to its rapid operation, was more suitable for 11C-radiopharmaceuticals. A sample volume of approx 0.5 mL can be injected onto a preparative HPLC column in over 90% efficiency with the present automated system.

AB - The injection of a radioactive reaction mixture into a preparative HPLC column has been automated with computer control for rapid purification of routinely prepared positron emitting radiopharmaceuticals. Using pneumatic valves, a motor-driven pump and a liquid level sensor, two intelligent injection methods for the automation were compared with regard to efficient and rapid sample loading into a 2 mL loop of the 6-way valve. One, a precise but rather slow method, was demonstrated to be suitable for purification of 18F-radiopharmaceuticals, while the other, due to its rapid operation, was more suitable for 11C-radiopharmaceuticals. A sample volume of approx 0.5 mL can be injected onto a preparative HPLC column in over 90% efficiency with the present automated system.

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Automated injection of a radioactive sample for preparative HPLC with feedback control

Abstract

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