Automated injection of a radioactive sample for preparative HPLC with feedback control

Ren Iwata, Shigeki Yamazaki, Tatsuo Ido

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    The injection of a radioactive reaction mixture into a preparative HPLC column has been automated with computer control for rapid purification of routinely prepared positron emitting radiopharmaceuticals. Using pneumatic valves, a motor-driven pump and a liquid level sensor, two intelligent injection methods for the automation were compared with regard to efficient and rapid sample loading into a 2 mL loop of the 6-way valve. One, a precise but rather slow method, was demonstrated to be suitable for purification of 18F-radiopharmaceuticals, while the other, due to its rapid operation, was more suitable for 11C-radiopharmaceuticals. A sample volume of approx 0.5 mL can be injected onto a preparative HPLC column in over 90% efficiency with the present automated system.

    Original languageEnglish
    Pages (from-to)1225-1227
    Number of pages3
    JournalInternational Journal of Radiation Applications and Instrumentation. Part
    Issue number12
    Publication statusPublished - 1990

    ASJC Scopus subject areas

    • Radiation
    • Engineering(all)


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