Autocrine stimulation of interleukin 1β in acute myelogenous leukemia cells

K. Sakai, T. Hattori, M. Matsuoka, N. Asou, S. Yamamoto, K. Sagawa, K. Takatsuki

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1β antibody in a dose-dependent manner, but not by rabbit anti-IL-1α antibody. Culture supernatants of these leukemic cells contained IL-1 activity, which was specifically inhibited by addition of anti-IL-1β antibody, and Northern blot analysis detected intracellular IL-1β mRNA. These results indicated that autocrine secretion of IL-1β was involved in proliferation of some myelogenous leukemic cells.

Original languageEnglish
Pages (from-to)1597-1602
Number of pages6
JournalJournal of Experimental Medicine
Volume166
Issue number5
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology

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