A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1β antibody in a dose-dependent manner, but not by rabbit anti-IL-1α antibody. Culture supernatants of these leukemic cells contained IL-1 activity, which was specifically inhibited by addition of anti-IL-1β antibody, and Northern blot analysis detected intracellular IL-1β mRNA. These results indicated that autocrine secretion of IL-1β was involved in proliferation of some myelogenous leukemic cells.
|Number of pages||6|
|Journal||Journal of Experimental Medicine|
|Publication status||Published - 1987|
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