Abstract
A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1β antibody in a dose-dependent manner, but not by rabbit anti-IL-1α antibody. Culture supernatants of these leukemic cells contained IL-1 activity, which was specifically inhibited by addition of anti-IL-1β antibody, and Northern blot analysis detected intracellular IL-1β mRNA. These results indicated that autocrine secretion of IL-1β was involved in proliferation of some myelogenous leukemic cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1597-1602 |
| Number of pages | 6 |
| Journal | Journal of Experimental Medicine |
| Volume | 166 |
| Issue number | 5 |
| Publication status | Published - 1987 |
ASJC Scopus subject areas
- Immunology