Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

Michio Kawano, Toshio Hirano, Tadashi Matsuda, Tetsuya Taga, Yasuhiro Horii, Koji Iwato, Hideki Asaoku, Bo Tang, Osamu Tanabe, Hideo Tanaka, Atsushi Kuramoto, Tadamitsu Kishimoto

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Abstract

Human B cell stimulatory factor 2 (BSF-2) was originally characterized and isolated as a T cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin-producing cells1,2. Molecular cloning of the complementary DNA predicts that BSF-2 is a protein of relative molecular mass (Mr) 26,000 similar or identical to interferon β2, hybridoma plasmacytoma growth factor and hepatocyte stimulating factor3-7. IL-6 has been proposed as a name for this molecule8,9. It is now known that BSF-2 has a wide variety of biological functions and that its target cells are not restricted to normal B cells1,10. Responses are also seen in T cells11,12, plasmacytomas6, hepatocytes7,13, haematopoietic stem cells14, fibroblasts15 and rat phoeochromocytoma, PC 12 (Satoh, T. et al., manuscript in preparation). Of particular interest to this report is that human BSF-2 is a potent growth factor for murine plasmacytomas and hybridomas6,8,10. This observation suggested to us that constitutive expression of BSF-2 or its receptor could be responsible for the generation of human myelomas. In this study we report that myeloma cells freshly isolated from patients produce BSF-2 and express its receptors. Moreover, anti-BSF-2 antibody inhibits the in vitro growth of myeloma cells. This is direct evidence that an autocrine loop is operating in oncogenesis of human myelomas.

Original languageEnglish
Pages (from-to)83-85
Number of pages3
JournalNature
Volume332
Issue number6159
DOIs
Publication statusPublished - 1988 Jan 1

ASJC Scopus subject areas

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    Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., Kuramoto, A., & Kishimoto, T. (1988). Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature, 332(6159), 83-85. https://doi.org/10.1038/332083a0