Autoantibodies against β-crystallins induce lens epithelial cell damage and cataract formation in mice

D. P. Singh; S. C. Guru; T. Kikuchi; Toshiaki Abe; T. Shinohara

Autoantibodies against β-crystallins induce lens epithelial cell damage and cataract formation in mice

D. P. Singh, S. C. Guru, T. Kikuchi, Toshiaki Abe, T. Shinohara

Research output: Contribution to journal › Article › peer-review

Abstract

One-year-old B6C3/f mice, injected with β-crystallins emulsified with CFA, developed lens epithelial cell damage. Both serum transfer and mAb transfer studies clearly established that the autoimmune insult is induced by humoral immunity. Older mice were more susceptible to autoimmune insult than younger animals. Lens epithelial cell damage invariably proceeded to cortical and posterior subcapsular cataract formation. This mouse model of experimental autoimmune cataract formation will facilitate the exploration of the relation between immune phenomena and human age-related cataract.

Original language	English
Pages (from-to)	993-999
Number of pages	7
Journal	Journal of Immunology
Volume	155
Issue number	2
Publication status	Published - 1995 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Immunology

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abstract = "One-year-old B6C3/f mice, injected with β-crystallins emulsified with CFA, developed lens epithelial cell damage. Both serum transfer and mAb transfer studies clearly established that the autoimmune insult is induced by humoral immunity. Older mice were more susceptible to autoimmune insult than younger animals. Lens epithelial cell damage invariably proceeded to cortical and posterior subcapsular cataract formation. This mouse model of experimental autoimmune cataract formation will facilitate the exploration of the relation between immune phenomena and human age-related cataract.",

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AU - Shinohara, T.

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N2 - One-year-old B6C3/f mice, injected with β-crystallins emulsified with CFA, developed lens epithelial cell damage. Both serum transfer and mAb transfer studies clearly established that the autoimmune insult is induced by humoral immunity. Older mice were more susceptible to autoimmune insult than younger animals. Lens epithelial cell damage invariably proceeded to cortical and posterior subcapsular cataract formation. This mouse model of experimental autoimmune cataract formation will facilitate the exploration of the relation between immune phenomena and human age-related cataract.

AB - One-year-old B6C3/f mice, injected with β-crystallins emulsified with CFA, developed lens epithelial cell damage. Both serum transfer and mAb transfer studies clearly established that the autoimmune insult is induced by humoral immunity. Older mice were more susceptible to autoimmune insult than younger animals. Lens epithelial cell damage invariably proceeded to cortical and posterior subcapsular cataract formation. This mouse model of experimental autoimmune cataract formation will facilitate the exploration of the relation between immune phenomena and human age-related cataract.

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