Augmentation of interferon production after cell-differentiation of U937 cells by TPA

Tomokazu Indoh, Sachiko Shirakawa, Tohru Kubota, Teruo Yashiki, Emiko Isogai, Nobuhiro Fujii

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Persistent infections with mumps virus were established in several human lymphoid cells of T-cell origin (Molt-4, TALL-1, and CCRF-CEM) and human monocyte cells (U937 and THP-1). 2',5'-Oligoadenylate synthetase (2-5AS) activity was demonstrated to be only slightly induced by interferon (IFN) or TPA (12-O-tetradecanoyl-phorbol-13-acetate) treatment in these cells. Treatment of the persistently infected cells with IFN or TPA did not stimulate an increase in the amount of synthetase mRNA. Induction of cell differentiation and augmentation of IFN production by TPA were demonstrated in U937 cells persistently infected with mumps virus (U937-MP). Similar results for IFN production were obtained from differentiated U937 cells. It is suggested that cell differentiation of U937 cells might be associated with the development of IFN inducibility.

Original languageEnglish
Pages (from-to)675-679
Number of pages5
Issue number9
Publication statusPublished - 1996
Externally publishedYes


  • 2',5'-Oligoadenylate synthetase
  • IFN
  • Mumps virus
  • Persistent infection
  • TPA
  • U937

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology


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