Augmentation of interferon production after cell-differentiation of U937 cells by TPA

Tomokazu Indoh; Sachiko Shirakawa; Tohru Kubota; Teruo Yashiki; Emiko Isogai; Nobuhiro Fujii

doi:10.1111/j.1348-0421.1996.tb01127.x

Augmentation of interferon production after cell-differentiation of U937 cells by TPA

Tomokazu Indoh, Sachiko Shirakawa, Tohru Kubota, Teruo Yashiki, Emiko Isogai, Nobuhiro Fujii

AGR - Bioscience and Biotechnology for Future Bioindustries

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5 Citations (Scopus)

Abstract

Persistent infections with mumps virus were established in several human lymphoid cells of T-cell origin (Molt-4, TALL-1, and CCRF-CEM) and human monocyte cells (U937 and THP-1). 2',5'-Oligoadenylate synthetase (2-5AS) activity was demonstrated to be only slightly induced by interferon (IFN) or TPA (12-O-tetradecanoyl-phorbol-13-acetate) treatment in these cells. Treatment of the persistently infected cells with IFN or TPA did not stimulate an increase in the amount of synthetase mRNA. Induction of cell differentiation and augmentation of IFN production by TPA were demonstrated in U937 cells persistently infected with mumps virus (U937-MP). Similar results for IFN production were obtained from differentiated U937 cells. It is suggested that cell differentiation of U937 cells might be associated with the development of IFN inducibility.

Original language	English
Pages (from-to)	675-679
Number of pages	5
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	40
Issue number	9
DOIs	https://doi.org/10.1111/j.1348-0421.1996.tb01127.x
Publication status	Published - 1996

Keywords

2',5'-Oligoadenylate synthetase
IFN
Mumps virus
Persistent infection
TPA
U937

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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10.1111/j.1348-0421.1996.tb01127.x

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title = "Augmentation of interferon production after cell-differentiation of U937 cells by TPA",

abstract = "Persistent infections with mumps virus were established in several human lymphoid cells of T-cell origin (Molt-4, TALL-1, and CCRF-CEM) and human monocyte cells (U937 and THP-1). 2',5'-Oligoadenylate synthetase (2-5AS) activity was demonstrated to be only slightly induced by interferon (IFN) or TPA (12-O-tetradecanoyl-phorbol-13-acetate) treatment in these cells. Treatment of the persistently infected cells with IFN or TPA did not stimulate an increase in the amount of synthetase mRNA. Induction of cell differentiation and augmentation of IFN production by TPA were demonstrated in U937 cells persistently infected with mumps virus (U937-MP). Similar results for IFN production were obtained from differentiated U937 cells. It is suggested that cell differentiation of U937 cells might be associated with the development of IFN inducibility.",

keywords = "2',5'-Oligoadenylate synthetase, IFN, Mumps virus, Persistent infection, TPA, U937",

author = "Tomokazu Indoh and Sachiko Shirakawa and Tohru Kubota and Teruo Yashiki and Emiko Isogai and Nobuhiro Fujii",

year = "1996",

doi = "10.1111/j.1348-0421.1996.tb01127.x",

language = "English",

volume = "40",

pages = "675--679",

journal = "Microbiology and Immunology",

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AU - Indoh, Tomokazu

AU - Shirakawa, Sachiko

AU - Kubota, Tohru

AU - Yashiki, Teruo

AU - Isogai, Emiko

AU - Fujii, Nobuhiro

PY - 1996

Y1 - 1996

N2 - Persistent infections with mumps virus were established in several human lymphoid cells of T-cell origin (Molt-4, TALL-1, and CCRF-CEM) and human monocyte cells (U937 and THP-1). 2',5'-Oligoadenylate synthetase (2-5AS) activity was demonstrated to be only slightly induced by interferon (IFN) or TPA (12-O-tetradecanoyl-phorbol-13-acetate) treatment in these cells. Treatment of the persistently infected cells with IFN or TPA did not stimulate an increase in the amount of synthetase mRNA. Induction of cell differentiation and augmentation of IFN production by TPA were demonstrated in U937 cells persistently infected with mumps virus (U937-MP). Similar results for IFN production were obtained from differentiated U937 cells. It is suggested that cell differentiation of U937 cells might be associated with the development of IFN inducibility.

AB - Persistent infections with mumps virus were established in several human lymphoid cells of T-cell origin (Molt-4, TALL-1, and CCRF-CEM) and human monocyte cells (U937 and THP-1). 2',5'-Oligoadenylate synthetase (2-5AS) activity was demonstrated to be only slightly induced by interferon (IFN) or TPA (12-O-tetradecanoyl-phorbol-13-acetate) treatment in these cells. Treatment of the persistently infected cells with IFN or TPA did not stimulate an increase in the amount of synthetase mRNA. Induction of cell differentiation and augmentation of IFN production by TPA were demonstrated in U937 cells persistently infected with mumps virus (U937-MP). Similar results for IFN production were obtained from differentiated U937 cells. It is suggested that cell differentiation of U937 cells might be associated with the development of IFN inducibility.

KW - 2',5'-Oligoadenylate synthetase

KW - IFN

KW - Mumps virus

KW - Persistent infection

KW - TPA

KW - U937

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Augmentation of interferon production after cell-differentiation of U937 cells by TPA

Abstract

Keywords

ASJC Scopus subject areas

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