TY - JOUR
T1 - Atypical teratoid/rhabdoid tumour with leptomeningeal dissemination in an adult
AU - Kawaguchi, T.
AU - Kumabe, Toshihiro
AU - Watanabe, M.
AU - Tominaga, T.
PY - 2004/9
Y1 - 2004/9
N2 - A 22-year-old man presented with a rare case of atypical teratoid/ rhabdoid tumour (AT/RT). Magnetic resonance imaging showed a left cerebellar mass with leptomeningeal dissemination. Partial resection was performed. Histological examination revealed AT/RT. Postoperatively, whole neuraxis and local irradiation were performed. Three-drug chemotherapy with ifosfamide, cisplatin, and etoposide, and adjuvant intrathecal administration of methotrexate were repeated. Near complete response was achieved, and no tumour recurrence/progression has been noticed during the follow up of 24 months. Intensive radiochemotherapy can successfully control AT/RT, even with leptomeningeal dissemination.
AB - A 22-year-old man presented with a rare case of atypical teratoid/ rhabdoid tumour (AT/RT). Magnetic resonance imaging showed a left cerebellar mass with leptomeningeal dissemination. Partial resection was performed. Histological examination revealed AT/RT. Postoperatively, whole neuraxis and local irradiation were performed. Three-drug chemotherapy with ifosfamide, cisplatin, and etoposide, and adjuvant intrathecal administration of methotrexate were repeated. Near complete response was achieved, and no tumour recurrence/progression has been noticed during the follow up of 24 months. Intensive radiochemotherapy can successfully control AT/RT, even with leptomeningeal dissemination.
KW - Atypical teratoid/rhabdoid tumour
KW - Chemotherapy
KW - Leptomeningeal dissemination
KW - Radiation
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U2 - 10.1007/s00701-004-0313-5
DO - 10.1007/s00701-004-0313-5
M3 - Article
C2 - 15340816
AN - SCOPUS:4544303295
VL - 146
SP - 1033
EP - 1038
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
SN - 0001-6268
IS - 9
ER -