Apresentações atípicas da neuromielite óptica

Translated title of the contribution: Atypical presentations of neuromyelitis optica

Douglas Sato, Kazuo Fujihara

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)

Abstract

Neuromyelitis optica (NMO) is an inflammatory disease of central nervous system classically characterized by acute, severe episodes of optic neuritis and longitudinally extensive transverse myelitis, usually with a relapsing course. The identification of an autoantibody exclusively detected in NMO patients against aquaporin-4 (AQP-4) has allowed identification of cases beyond the classical phenotype. Brain lesions, once thought as infrequent, can be observed in NMO patients, but lesions have different characteristics from the ones seen in multiple sclerosis. Additionally, some AQP-4 antibody positive patients may present with a variety of symptoms not being restricted to optic neuritis and acute myelitis during the first attack or in a relapse. Examples are not limited to, but may include patients only with brain and/or brainstem lesions, narcolepsy with hypothalamic lesions or patients with intractable hiccups, nausea and vomiting. The prompt identification of NMO patients with atypical presentations may benefit these patients with institution of early treatment to reduce disability and prevent further attacks.

Translated title of the contributionAtypical presentations of neuromyelitis optica
Original languagePortuguese
Pages (from-to)824-828
Number of pages5
JournalArquivos de Neuro-Psiquiatria
Volume69
Issue number5
DOIs
Publication statusPublished - 2011 Oct

Keywords

  • Aquaporin 4
  • Brain diseases
  • Diagnosis
  • Differential
  • Hiccup
  • Myelitis
  • Nausea
  • Neuromyelitis optica
  • Optic neuritis
  • Vomiting

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry

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