Atypical carcinoid of the larynx and expressions of proteins associated with molecular targeted therapy

Takeharu Kanazawa, Mitsuhiro Nokubi, Katsuji Takeoda, Kozue Kodama, Hajime Usubuchi, Yukiko Iino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: We reported an extremely rare case of atypical laryngeal carcinoid, and examined the expression of several proteins for application of molecular targeted therapy. Method: Case report and review of the literature concerning atypical carcinoid arising from the larynx. The expressions of proteins were determined by immunohistochemical analysis. Results: We present here a case of atypical laryngeal carcinoid in a 79-year-old Japanese man, which was completely resected, and with no evidence of recurrence. On immunohistochemical analysis, neoplastic elements revealed, strong positivity for platelet-derived growth factor receptor α (PDGFRα), vascular endothelial growth factor receptor 2 (VEGFR2), and epidermal growth factor receptor (EGFR), and were mild positivity for KIT. Conclusion: Our findings suggest that atypical laryngeal carcinoid could be completely removed if it is located in the limited lesion. PDGFRα, VEGFR2, and EGFR expressions in this case provide the evidence that atypical laryngeal carcinoid is the candidate for molecular targeted therapy, although further investigations are necessary.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalAuris Nasus Larynx
Volume38
Issue number1
DOIs
Publication statusPublished - 2011 Feb 1
Externally publishedYes

Keywords

  • Atypical laryngeal carcinoid
  • Case report
  • Immunohistochemical analysis
  • Molecular targeted therapy

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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