TY - JOUR
T1 - Atypical carcinoid of the larynx and expressions of proteins associated with molecular targeted therapy
AU - Kanazawa, Takeharu
AU - Nokubi, Mitsuhiro
AU - Takeoda, Katsuji
AU - Kodama, Kozue
AU - Usubuchi, Hajime
AU - Iino, Yukiko
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Objective: We reported an extremely rare case of atypical laryngeal carcinoid, and examined the expression of several proteins for application of molecular targeted therapy. Method: Case report and review of the literature concerning atypical carcinoid arising from the larynx. The expressions of proteins were determined by immunohistochemical analysis. Results: We present here a case of atypical laryngeal carcinoid in a 79-year-old Japanese man, which was completely resected, and with no evidence of recurrence. On immunohistochemical analysis, neoplastic elements revealed, strong positivity for platelet-derived growth factor receptor α (PDGFRα), vascular endothelial growth factor receptor 2 (VEGFR2), and epidermal growth factor receptor (EGFR), and were mild positivity for KIT. Conclusion: Our findings suggest that atypical laryngeal carcinoid could be completely removed if it is located in the limited lesion. PDGFRα, VEGFR2, and EGFR expressions in this case provide the evidence that atypical laryngeal carcinoid is the candidate for molecular targeted therapy, although further investigations are necessary.
AB - Objective: We reported an extremely rare case of atypical laryngeal carcinoid, and examined the expression of several proteins for application of molecular targeted therapy. Method: Case report and review of the literature concerning atypical carcinoid arising from the larynx. The expressions of proteins were determined by immunohistochemical analysis. Results: We present here a case of atypical laryngeal carcinoid in a 79-year-old Japanese man, which was completely resected, and with no evidence of recurrence. On immunohistochemical analysis, neoplastic elements revealed, strong positivity for platelet-derived growth factor receptor α (PDGFRα), vascular endothelial growth factor receptor 2 (VEGFR2), and epidermal growth factor receptor (EGFR), and were mild positivity for KIT. Conclusion: Our findings suggest that atypical laryngeal carcinoid could be completely removed if it is located in the limited lesion. PDGFRα, VEGFR2, and EGFR expressions in this case provide the evidence that atypical laryngeal carcinoid is the candidate for molecular targeted therapy, although further investigations are necessary.
KW - Atypical laryngeal carcinoid
KW - Case report
KW - Immunohistochemical analysis
KW - Molecular targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=78651309395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78651309395&partnerID=8YFLogxK
U2 - 10.1016/j.anl.2010.05.008
DO - 10.1016/j.anl.2010.05.008
M3 - Article
C2 - 20580173
AN - SCOPUS:78651309395
VL - 38
SP - 123
EP - 126
JO - Auris Nasus Larynx
JF - Auris Nasus Larynx
SN - 0385-8146
IS - 1
ER -