Attraction versus Repulsion in Rhodium-Catalyzed Asymmetric Hydrogenation

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11 Citations (Scopus)

Abstract

For several decades of intensive research it has been accepted that the physical sizes and shapes of substituents are the main stereoregulating factors in Rh-catalyzed asymmetric hydrogenation. In this paper, it is argued on the basis of accumulated experimental and computational evidence that weak noncovalent attractive interactions between the substituents of the chiral ligand and the substrate strongly contribute to the process of stereoselection in Rh-catalyzed asymmetric hydrogenation in the same fashion as that observed in organocatalytic reactions and in biological enzymatic processes.

Original languageEnglish
Pages (from-to)3463-3468
Number of pages6
JournalChemCatChem
Volume8
Issue number22
DOIs
Publication statusPublished - 2016 Nov 22

Keywords

  • asymmetric catalysis
  • enantioselectivity
  • hydrogenation
  • noncovalent interactions
  • rhodium

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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