ATTENUATED RENAL RESPONSE TO ATRIAL NATRIURETIC PEPTIDE INFUSION IN RATS WITH HEART FAILURE

Masahiro Kohzuki, G. Peter Hodsman, Richard W. Harrison, Colin I. Johnston

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume15
Issue number4
DOIs
Publication statusPublished - 1988 Jan 1
Externally publishedYes

Keywords

  • atrial natriuretic peptide
  • blood pressure
  • diuresis
  • myocardial infarction
  • natriuresis.

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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