ATTENUATED RENAL RESPONSE TO ATRIAL NATRIURETIC PEPTIDE INFUSION IN RATS WITH HEART FAILURE

Masahiro Kohzuki; G. Peter Hodsman; Richard W. Harrison; Colin I. Johnston

doi:10.1111/j.1440-1681.1988.tb01081.x

ATTENUATED RENAL RESPONSE TO ATRIAL NATRIURETIC PEPTIDE INFUSION IN RATS WITH HEART FAILURE

Masahiro Kohzuki, G. Peter Hodsman, Richard W. Harrison, Colin I. Johnston

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.

Original language	English
Pages (from-to)	323-326
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	15
Issue number	4
DOIs	https://doi.org/10.1111/j.1440-1681.1988.tb01081.x
Publication status	Published - 1988 Jan 1
Externally published	Yes

Keywords

atrial natriuretic peptide
blood pressure
diuresis
myocardial infarction
natriuresis.

ASJC Scopus subject areas

Physiology
Pharmacology
Physiology (medical)

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10.1111/j.1440-1681.1988.tb01081.x

Cite this

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title = "ATTENUATED RENAL RESPONSE TO ATRIAL NATRIURETIC PEPTIDE INFUSION IN RATS WITH HEART FAILURE",

abstract = "1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.",

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year = "1988",

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doi = "10.1111/j.1440-1681.1988.tb01081.x",

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T1 - ATTENUATED RENAL RESPONSE TO ATRIAL NATRIURETIC PEPTIDE INFUSION IN RATS WITH HEART FAILURE

AU - Kohzuki, Masahiro

AU - Hodsman, G. Peter

AU - Harrison, Richard W.

AU - Johnston, Colin I.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - 1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.

AB - 1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.

KW - atrial natriuretic peptide

KW - blood pressure

KW - diuresis

KW - myocardial infarction

KW - natriuresis.

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JO - Clinical and Experimental Pharmacology and Physiology

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ATTENUATED RENAL RESPONSE TO ATRIAL NATRIURETIC PEPTIDE INFUSION IN RATS WITH HEART FAILURE

Abstract

Keywords

ASJC Scopus subject areas

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