Attempts to induce immune-mediated cerebral arterial injury for an experimental model of moyamoya disease

Masayuki Ezura, Satoru Fujiwara, Masato Nose, Takashi Yoshimoto, Masahisa Kyogoku

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

To examine the possible role of immune complex-mediated reactions in moyamoya disease, a novel experimental system using a serum sickness vasculitis model combined with intracisternal administration of antibodies or antigens was developed. Twenty-eight male Japanese white rabbits were divided into four experimental groups. Group I was treated twice with intravenous injections of heterologous serum. In group II, intracisternal administration of antibodies or antigens was combined with the second injection of serum. Group III received a single intravenous injection of antigens simulaneously with intracisternal administration of antibodies. Group IV was a technical control group. Cerebral arteritis, although likely in the initial process, was induced only in groups II and III. This study suggests that the cerebral arteries rarely develop arteritis in a serum sickness model alone. The cerebral arteries may require additional intracisternal administration of antibodies or antigens to induce in situ deposition of immune complexes around them.

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalChild's Nervous System
Volume8
Issue number5
DOIs
Publication statusPublished - 1992 Aug

Keywords

  • Cerebral arterial injury
  • Cerebral arteritis
  • Experimental model
  • Intracisternal injection
  • Moyamoya disease
  • Serum sickness

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Attempts to induce immune-mediated cerebral arterial injury for an experimental model of moyamoya disease'. Together they form a unique fingerprint.

Cite this