ATP transport in saccular cerebral aneurysms at arterial bends

Yohsuke Imai, Kodai Sato, Takuji Ishikawa, Andrew Comerford, Tim David, Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

ATP acts as an extracellular signaling molecule in purinergic signaling that regulates vascular tone. ATP binds purinergic P2 nucleotide receptors on endothelial cells. Understanding the mass transport of ATP to endothelial cells by blood flow is thus important to predict functional changes in aneurysmal walls. While some clinical observations indicate a difference of wall pathology between ruptured and unruptured aneurysms, no study has focused on the mass transport in aneurysms. We investigated the characteristics of ATP concentration at aneurysmal wall using a numerical model of ATP transport in aneurysms formed at arterial bends. The magnitude of ATP concentration at the aneurysmal wall was significantly smaller than that at the arterial wall. In particular, significantly low concentration was predicted at the proximal side of the aneurysmal sac. A strong correlation was revealed between the inflow flux at the aneurysmal neck and the resultant concentration at the aneurysmal wall.

Original languageEnglish
Pages (from-to)927-934
Number of pages8
JournalAnnals of Biomedical Engineering
Volume38
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

Keywords

  • Arterial bend
  • Blood flow
  • Cerebral aneurysm
  • Mass transport
  • Nucleotide concentration
  • Purinergic signaling

ASJC Scopus subject areas

  • Biomedical Engineering

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