ATP-sensitive K+ channel opener pinacidil augments β1-adrenoceptor- induced coronary vasodilation in dogs

Yousuke Katsuda, Kensuke Egashira, Hideki Ueno, Yukinori Arai, Yutaka Akatsuka, Takeshi Kuga, Hiroaki Shimokawa, Akira Takeshita

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The opening of ATP-sensitive K+ (K(ATP)/+) channels contributes to the mechanism of metabolic coronary vasodilation. The aim of the present study was to determine whether K(ATP)/+ channel opener pinacidil augments coronary vasodilation induced by β-adrenoceptor stimulation. In anesthetized dogs, coronary vasodilation in response to intracoronary infusion of a β1- adrenoceptor agonist denopamine, selective β2-adrenoceptor stimulation with isoproterenol after bisoprolol or nitroglycerin was studied before and during simultaneous intracoronary infusion of pinacidil at a dose of 1 μg/min, which had no effect on basal hemodynamics. Pinacidil augmented the denopamine-induced increase in coronary blood flow (CBF) from 38 ± 9 to 66 ± 16% (P < 0.05) but did not affect the denopamine-induced increase in myocardial oxygen consumption (MV̇O2). Pinacidil had no effect on the increases in CBF or MV̇O2 induced by isoproterenol or nitroglycerin. Thus pinacidil selectively augmented β1-adrenoceptor-mediated coronary vasodilation. These observations suggest that the K(ATP)/+ channel opener pinacidil may increase myocardial perfusion during metabolic stress associated with β1-adrenoceptor stimulation.

Original languageEnglish
Pages (from-to)H2210-H2215
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume270
Issue number6 39-6
DOIs
Publication statusPublished - 1996 Jun
Externally publishedYes

Keywords

  • coronary circulation
  • metabolic coronary vasodilation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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