Atopic dermatitis without serum immunoglobulin E elevation or loss-of-function filaggrin gene mutation in a patient with X-linked agammaglobulinemia

Emi Yamazaki, Katsuko Kikuchi, Yoji Sasahara, Michihiro Kono, Masashi Akiyama, Setsuya Aiba

Research output: Contribution to journalArticle

Abstract

A case of atopic dermatitis (AD) with X-linked agammaglobulinemia (XLA), which is one of the primary immunodeficiency diseases, is reported. A 12-year-old boy had suffered from dry skin and recurrent itchy eruptions since he was 2 years old, and he was diagnosed as having XLA at the age of 4 years. His total immunoglobulin (Ig)E level was 7 IU/mL, even with regular Ig replacement therapy. Furthermore, filaggrin (FLG) mutations known in the Japanese population were not found. His skin lesions were well controlled by the application of a mild-class topical steroid and a moisturizer, though he developed folliculitis due to Staphylococcus aureus infection during treatment with a strong-class topical steroid. This case suggests that the FLG mutation and IgE-mediated sensitization are not necessary to induce AD skin manifestation.

Original languageEnglish
Pages (from-to)58-60
Number of pages3
JournalJournal of Dermatology
Volume47
Issue number1
DOIs
Publication statusPublished - 2020 Jan 1

Keywords

  • X-linked agammaglobulinemia
  • atopic dermatitis (eczema)
  • filaggrin gene mutations
  • immunoglobulin E
  • primary immunodeficiency disease

ASJC Scopus subject areas

  • Dermatology

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